- Meta-Selective C-H Borylation of Benzamides and Pyridines by an Iridium-Lewis Acid Bifunctional Catalyst
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We report herein the iridium-catalyzed meta-selective C-H borylation of benzamides by using a newly designed 2,2′-bipyridine (bpy) ligand bearing an alkylaluminum biphenoxide moiety. We also demonstrate the iridium-catalyzed C3-selective C-H borylation of pyridine with a 1,10-phenanthroline (Phen) ligand bearing an alkylborane moiety. It is proposed that the Lewis acid-base interaction between the Lewis acid moiety and the aminocarbonyl group or the sp2-hybridized nitrogen atom accelerates the reaction and controls the site-selectivity.
- Yang, Lichen,Uemura, Nao,Nakao, Yoshiaki
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supporting information
p. 7972 - 7979
(2019/05/22)
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- Synthesis of benzoxazoles from 2-aminophenols and β-diketones using a combined catalyst of br?nsted acid and copper iodide
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Cyclization reactions of 2-aminophenols with β-diketones catalyzed by a combination of Br?nsted acid and CuI are presented. Various 2-substituted benzoxazoles were obtained through these reactions. Different substituents such as methyl, chloro, bromo, nitro, and methoxy on 2-aminophenol are tolerated under the optimized reaction conditions.
- Mayo, Muhammad Shareef,Yu, Xiaoqiang,Zhou, Xiaoyu,Feng, Xiujuan,Yamamoto, Yoshinori,Bao, Ming
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p. 6310 - 6314
(2014/07/21)
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- A green route for the synthesis of 2-substituted benzoxazole derivatives catalyzed by Al3+-exchanged K10 clay
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A new, simple, and efficient protocol is developed for the synthesis of 2-substituted benzoxazole derivatives through N-C-O bond formation using Al 3+-exchanged K10 clay (Al3+-K10) as catalyst. A wide range of benzoxazole derivatives
- Suresh, Dhanusu,Dhakshinamoorthy, Amarajothi,Pitchumani, Kasi
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supporting information
p. 6415 - 6419
(2013/11/19)
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- 1,3-Dibromo-5,5-dimethylhydantoin as an efficient homogeneous catalyst for synthesis of benzoxazoles, benzimidazoles, and oxazolo[4,5-b]pyridines
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A simple and highly efficient method for synthesis of benzoxazoles, benzimidazoles, and oxazolo[4,5-b]pyridines is described. Condensation of orthoesters with o-substituted anilines or 2-amino-3-hydroxypyridine was performed in the presence of catalytic amounts of commercially available, inexpensive, and moisture-stable 1,3-dibromo-5,5-dimethylhydantoin under solvent-free conditions. The corresponding heterocycles were obtained in good to excellent yields. The main advantages of the present procedure are mild reaction conditions, short reaction times, high yields of products, easy work-up, and absence of solvent. Graphical abstract: [Figure not available: see fulltext.]
- Hojati, Seyedeh Fatemeh,Maleki, Behrooz,Beykzadeh, Zahra
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experimental part
p. 87 - 91
(2011/09/19)
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- Luminous Compound Containing Lanthanide Ion
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A luminous compound represented by the following formula (I): [in-line-formulae]Met-COG-ChHet??Formula (I)[/in-line-formulae] wherein Met represents a group containing a lanthanide ion, COG represents a heterocyclic group bonded directly to the lanthanide ion contained in the group represented by Met, and ChHet represents a group having a heterocycle, where ChHet is preferably a group that conjugates with COG.
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Page/Page column 13
(2009/10/06)
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- A rapid method for the preparation of 2-substituted oxazolo[4,5-b]pyridines using microwave-assisted direct condensation reactions
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The condensation reaction of 2-amino-3-hydroxypyridine with different carboxylic acids by microwave-assisted heating is a fast method for producing libraries based on fused 2-substituted oxazolo[4,5-b]pyridines in moderate to good yields.
- Myllym?ki, Mikko J.,Koskinen, Ari M.P.
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p. 2295 - 2298
(2007/10/03)
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- Mild and efficient synthesis of benzoxazoles, benzothiazoles, benzimidazoles, and oxazolo[4,5-b]pyridines catalyzed by Bi(III) salts under solvent-free conditions
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A series of benzoxazoles, benzothiazoles, benzimidazoles, and oxazolo[4,5-b]pyridines was efficiently synthesized from the reactions of o-aminophenols, o-aminothiophenol, o-phenylenediamines, and 2-amino-3- hydroxypyridine with orthoesters in the presence of catalytic amounts of Bi(III) salts, such as Bi(TFA)3, Bi(OTf)3, and BiOClO4 ? xH2O under solvent-free conditions. The remarkable features of this new protocol are high conversion, very short reaction times, cleaner reaction profiles under solvent-free conditions, straightforward procedure, and use of relatively non-toxic catalysts. Springer-Verlag 2007.
- Mohammadpoor-Baltork, Iraj,Khosropour, Ahmad R.,Hojati, Seyedeh F.
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p. 663 - 667
(2008/02/07)
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- Method for optical measurement of multi-stranded nucleic acid using cyanine dyes
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A method for optical measurement of a multi-stranded nucleic acid which comprises the step of bringing a compound into contact with a multi-stranded nucleic acid wherein said compound is capable of interacting with the multi-stranded nucleic acid, wherein the compound has the following properties:(a) the compound can exist in a substantially colorless and non-fluorescent state under at least one condition in an aqueous solution in the absence of the multi-stranded nucleic acid, and(b) when the multi-stranded nucleic acid is allowed to exist in the condition defined in the above (a), the compound changes to a substantially colored state based on an interaction with the multi-stranded nucleic acid and substantially expresses fluorescent property based on said interaction.
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- SYNTHESIS OF 2-(4-ARYL-1E,3E-BUTADIENYL)BENZOXAZOLES BY THE HORNER-WADSWORTH-EMMONS REACTION
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2-(4-Aryl-1E,3E-butadienyl)benzoxazole derivatives were synthesized by the Horner-Wadsworth-Emmons reaction of 2-phosphorylmethylbenzoxazoles with cinnamaldehydes in fair to good yield.
- Kosaka, Takatoshi,Wakabayashi, Toshio
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p. 477 - 486
(2007/10/02)
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- Syntheses of oxazolo[4,5-b]pyridenes and [4,5-d]pyrimidines
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Oxazolo[4,5-b]pyridines and [4,5-d]pyrimidines and their 2-substituted compounds have been prepared respectively by condensation of orthoesters of thioimidates derivatives with 2-amino-3-hydroxypyridine and 4-amino-5-hydroxypyrimidine.
- Doise,Blondeau,Sliwa
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p. 2891 - 2901
(2007/10/02)
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- Synthesis of novel heterocycles: Oxazolo[4,5-b]pyridines and oxazolo[4,5-d]pyrimidines
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Novel purine isosters (title compounds) have been prepared by condensation of the appropriate o-hydroxyaminoazine with ethyl orthoformate; extension to other orthoesters and to benzyl thioacetimidate afford 2-alkyl substituted derivatives of these new fus
- Doise,Dennin,Blondeau,Sliwa
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p. 1155 - 1156
(2007/10/02)
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- FACILE SYNTHESIS OF SOME OXAZOLOPYRIDINES AND THEIR N-OXIDES VIA INTRAMOLECULAR CYCLIZATION
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A convenient synthesis of 3-methylisoxazolopyridine 2, 2-methyloxazolopyridine 4 and their N-oxides (12, 17 and 18) is reported.The configurations of the oximes used for the synthesis of the compounds described above are discussed through chemical and spectral studies.
- Tagawa, Yoshinobu,Goto, Yoshinobu
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p. 2921 - 2939
(2007/10/02)
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