cas 865998-46-5, ETHYL 4-NITRO-1H-IMIDAZOLE-2-CARBOXYLATE | Articles data ｜lookchem

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865998-46-5

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WDR5-MYC INHIBITORS
Substituted N-heteroaryl sulfonamide compounds inhibit WDR5-MYC interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject such as cancer cell proliferation.
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Paragraph 00101; 00202

(2021/05/29)

Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis
Diarrhoeal diseases caused by the intestinal parasites Giardia lamblia and Entamoeba histolytica constitute a major global health burden. Nitroimidazoles are first-line drugs for the treatment of giardiasis and amebiasis, with metronidazole 1 being the mo
Jarrad,Debnath,Miyamoto,Hansford,Pelingon,Butler,Bains,Karoli,Blaskovich,Eckmann,Cooper
supporting information
p. 353 - 362
(2016/06/06)

Orthogonally positioned diamino pyrrole- and imidazole-containing polyamides: Synthesis of 1-(3-substituted-propyl)-4-nitropyrrole-2-carboxylic acid and 1-(3-Chloropropyl)-4-nitroimidazole-2-carboxylic Acid
Pyrrole- and imidazole-containing polyamides can be tailored to recognize the DNA 6-8 base pair sequence. We found that adding a second amino group via the N1-position of pyrrole or imidazole in polyamides could enhance their DNA binding affinity and wate
Satam, Vijay,Patil, Pravin,Babu, Balaji,Rice, Toni,Porte, Alexander,Alger, Shannon,Zeller, Matthias,Lee, Moses
p. 968 - 975
(2014/03/21)

Synthesis of Substituted Imidazo[1, 5-a]pyrimidines, 1H-pyrrolo[2, 3-b]pyridines and 3-methyl-3H-imidazo[4, 5-b]pyridines
Cyclization of in situ generated 5-aminoimidazoles with various malondialdehydes or 1, 3-diketones gave substituted imidazo[1, 5-a]pyrimidines. However, cyclization of 2-aminopyrroles and 5-amino-1-methylimidazoles resulted in condensations on a carbon at
Wu, Jingshing,Xing, Xuechao,Cuny, Gregory D.
scheme or table
p. 203 - 207
(2010/04/23)

HETEROCYCLYLAMIDE-SUBSTITUTED IMIDAZOLES
The invention relates to heterocyclylamide-substituted imidazoles and methods for the production of the same, to the use thereof for the treatment and/or prophylaxis of diseases, to the use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases, and especially to the use thereof as antiviral agents, especially against cytomegaloviruses.
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Page/Page column 14; 23

(2008/06/13)

ANTIVIRAL 4-AMINOCARBONYLAMINO-SUBSTITUTED IMIDAZOLE COMPOUND
The invention relates to the substituted imidazoles of formula (I) and to methods for producing the same, to their use in the treatment and/or prophylaxis of diseases and to their use for producing drugs for use in the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against cytomegaloviruses.
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Page/Page column 33

(2010/02/14)

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Chemical Properties

Boiling Point: 405.4 °C at 760 mmHg
Flash Point:199 °C
Density: 1.455 g/cm³
Storage Temp.:2-8°C
PKA: 6.48±0.10(Predicted)
PSA: 100.80000
LogP: 1.01780

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