cas 866823-73-6, Biphenylindanone A | Articles data ｜lookchem

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866823-73-6

Articles about 866823-73-6Total 3 be found

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Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice
Previous studies indicate that agonists of the group II metabotropic glutamate receptors (mGluRs), mGluR2 and mGluR3, may provide a novel approach for the treatment of anxiety disorders and schizophrenia. However, the relative contributions of the mGluR2
Galici, Ruggero,Jones, Carrie K.,Hemstapat, Kamondanai,Nong, Yi,Echemendia, Nicholas G.,Williams, Lilly C.,De Paulis, Tomas,Conn, P. Jeffrey
p. 173 - 185
(2008/01/27)

INDANONE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS
The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutama
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Page/Page column 55

(2008/06/13)

Biphenyl-indanones: Allosteric potentiators of the metabotropic glutamate subtype 2 receptor
We have identified and synthesized a series of biphenyl-carboxylic acid indanones as allosteric potentiators of the metabotropic glutamate receptor 2. Structure-activity relationship studies directed toward improving the potency and the brain to plasma ra
Bonnefous, Celine,Vernier, Jean-Michel,Hutchinson, John H.,Gardner, Michael F.,Cramer, Merryl,James, Joyce K.,Rowe, Blake A.,Daggett, Lorrie P.,Schaffhauser, Herve,Kamenecka, Theodore M.
p. 4354 - 4358
(2007/10/03)

More Articles about upstream products of 866823-73-6

Chemical Properties

Melting Point: 238-241℃
Density: 1.220
Solubility:DMSO: ≥18mg/mL
Storage Temp.:Desiccate at RT
PSA: 63.60000
LogP: 6.79280

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