- Preparation method of olodaterol and salts thereof
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The invention relates to a preparation method of olodaterol and salts thereof, which comprises the following steps: in a solvent, carrying out oxidation and nucleophilic addition reaction on a compound shown in a formula I to obtain a compound shown in a
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- IMPROVED PROCESS FOR THE MANUFACTURE OF R-6-HYDROXY-8-[1-HYDROXY-2-[2-(4-METHOXYPHENYL)-1,1-DIMETHYLETHYLAMINOETHYL]-2H-1,4-BENZOXAZIN-3(4H)-ONE HYDROCHLORIDE
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The present invention provides an improved process for the manufacture (R)-6- hydroxy-8-[1-hydroxy-2-[2-(4-methoxyphenyl)-1,1-dimethyl-ethylamino-ethyl]-2H-1,4- benzoxazin-3(4H)-one, in high purity and high yield, through the use of 1,1-dimethyl-2- (4-met
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Page/Page column 40; 42
(2018/07/29)
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- Hydrochloric acid [...] B and its preparation method
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The invention relates to a long-acting β2 Adrenal can agonist pharmaceutical hydrochloride crystalline form of [...] B and its preparation method, B and containing said form of the pharmaceutical composition, this crystalline form to its X-ray
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Paragraph 0065; 0070; 0071
(2019/01/08)
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- Crystal form C of olodaterol hydrochloride and preparation method thereof
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The invention relates to a crystal form C of a long-acting beta2 adrenergic agonist olodaterol hydrochloride and a preparation method thereof and a pharmaceutical composition containing the crystal form C. The crystal form is represented by the characteri
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Paragraph 0063; 0068; 0069
(2018/11/27)
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- A Process for Preparing Olodaterol and Intermediates Thereof
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The present invention relates to a process for preparing olodaterol and intermediates thereof. The process comprises of forming compound of Formula 1 by reacting compound of Formula 2 or its acid salt with compound of Formula 3 in the presence of an organ
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Paragraph 0071
(2017/09/24)
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- PROCESS FOR THE MANUFACTURING OF BETA MIMETICS
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The invention relates to a method for producing betamimetics of formula (1), wherein in which n represents 1 or 2; R1 represents hydrogen, halogen, C1-4-alkyl or O—C1-4-alkyl; R2 represents hydrogen, halogen, C
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Page/Page column 5
(2010/02/17)
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- Discovery of olodaterol, a novel inhaled β2-adrenoceptor agonist with a 24 h bronchodilatory efficacy
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Compound 4p was identified from a series of 6-hydroxy-4H-benzo[1,4]oxazin-3-ones as potent agonist of the human β2-adrenoceptor with a high β1/β2-selectivity. A complete reversal of acetylcholine-induced bronchoconstrictio
- Bouyssou, Thierry,Hoenke, Christoph,Rudolf, Klaus,Lustenberger, Philipp,Pestel, Sabine,Sieger, Peter,Lotz, Ralf,Heine, Claudia,Büttner, Frank H.,Schnapp, Andreas,Konetzki, Ingo
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body text
p. 1410 - 1414
(2010/07/10)
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- PROCESS FOR THE MANUFACTURING OF BETAMIMETICS
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The present invention relates to a process for preparing betamimetics of formula 1, wherein n denotes 1 or 2; R1 denotes hydrogen, halogen, C1-4-alkyl or O—C1-4-alkyl; R2 denotes hydrogen, halogen, C1-4/su
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Page/Page column 10
(2008/06/13)
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- New enentiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
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The present invention relates to enantiomerically pure compounds of general formula 1 wherein the groups R1, R2, R3, R4 and X? may have the meanings given in the claims and in the specification, proce
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Page/Page column 10
(2008/06/13)
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- NOVEL ENANTIOMERICALLY PURE BETA-AGONISTS, METHOD FOR THE PRODUCTION AND THE USE THEREOF IN THE FORM OF A DRUG
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The invention relates to enantiomerically pure compounds of formula (1), wherein the radicals R1, R2, R3, R4and X are defined as in claims and a description. A method for producing said compounds and the use thereof
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Page/Page column 18
(2008/06/13)
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- Aerosol formulation for the inhalation of beta-agonists
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The present invention relates to a propellant-free aerosol formulation which [contains] one or more compounds of general formula 1 wherein the groups R1, R2, R3 and X? may have the meanings given in the claims a
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Page/Page column 9
(2008/06/13)
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- Novel medicament combinations for the treatment of respiratory diseases
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The present invention relates to new medicament combinations which contain in addition to one or more, preferably one, compound of general formula 1 wherein the groups R1, R2 and R3 may have the meanings given in the claim
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Page/Page column 32
(2008/06/13)
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- Novel medicaments for the treatment of respiratory diseases
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The present invention relates to the use of the compounds of general formula 1 wherein the groups R1, R2 and R3 may have the meanings given in the claims and in the specification, for preparing a pharmaceutical composition
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Page/Page column 5-6
(2008/06/13)
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