- Preparation method of olodaterol and salts thereof
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The invention relates to a preparation method of olodaterol and salts thereof, which comprises the following steps: in a solvent, carrying out oxidation and nucleophilic addition reaction on a compound shown in a formula I to obtain a compound shown in a
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Paragraph 0063-0067
(2021/04/03)
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- Crystal form C of olodaterol hydrochloride and preparation method thereof
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The invention relates to a crystal form C of a long-acting beta2 adrenergic agonist olodaterol hydrochloride and a preparation method thereof and a pharmaceutical composition containing the crystal form C. The crystal form is represented by the characteri
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Paragraph 0063; 0064; 0065
(2018/11/27)
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- Olodaterol hydrochloride crystal form A and preparation method thereof
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The invention relates to a long-acting beta 2 adrenergic agonist drug olodaterol hydrochloride crystal form A, a preparation method thereof and and a pharmaceutical composition containing the crystalform A. The crystal form is characterized by X-ray diffr
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Paragraph 0074-0076
(2019/01/16)
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- Hydrochloric acid [...] B and its preparation method
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The invention relates to a long-acting β2 Adrenal can agonist pharmaceutical hydrochloride crystalline form of [...] B and its preparation method, B and containing said form of the pharmaceutical composition, this crystalline form to its X-ray
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Paragraph 0065-0067
(2019/01/08)
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- Benzoxazine compound and its preparation methods and application
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The invention relates to a benzoxazine compound represented in the following formula 1. The benzoxazine compound can serve as a beta 2 receptor agonist. The formula can be seen from the description.
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- PROCESS FOR THE MANUFACTURING OF BETA MIMETICS
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The invention relates to a method for producing betamimetics of formula (1), wherein in which n represents 1 or 2; R1 represents hydrogen, halogen, C1-4-alkyl or O—C1-4-alkyl; R2 represents hydrogen, halogen, C
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Page/Page column 6
(2010/02/17)
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- Discovery of olodaterol, a novel inhaled β2-adrenoceptor agonist with a 24 h bronchodilatory efficacy
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Compound 4p was identified from a series of 6-hydroxy-4H-benzo[1,4]oxazin-3-ones as potent agonist of the human β2-adrenoceptor with a high β1/β2-selectivity. A complete reversal of acetylcholine-induced bronchoconstrictio
- Bouyssou, Thierry,Hoenke, Christoph,Rudolf, Klaus,Lustenberger, Philipp,Pestel, Sabine,Sieger, Peter,Lotz, Ralf,Heine, Claudia,Büttner, Frank H.,Schnapp, Andreas,Konetzki, Ingo
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scheme or table
p. 1410 - 1414
(2010/07/10)
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- Novel Enantiomeric Pure Beta Agonists, Manufacturing and Use as a Medicament Thereof
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The present invention relates to enantiomerically pure compounds of formula 1 wherein the groups m, n, B, X, R1, m and Ym- may have the meanings given in the claims and specification, methods for preparing them and their use as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints.
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Page/Page column 11
(2008/06/13)
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- New enentiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
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The present invention relates to enantiomerically pure compounds of general formula 1 wherein the groups R1, R2, R3, R4 and X? may have the meanings given in the claims and in the specification, proce
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Page/Page column 7
(2008/06/13)
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- NOVEL ENANTIOMERICALLY PURE BETA-AGONISTS, METHOD FOR THE PRODUCTION AND THE USE THEREOF IN THE FORM OF A DRUG
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The invention relates to enantiomerically pure compounds of formula (1), wherein the radicals R1, R2, R3, R4and X are defined as in claims and a description. A method for producing said compounds and the use thereof
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Page/Page column 17
(2008/06/13)
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