Synthesis, in vitro covalent binding evaluation, and metabolism of 14C-labeled inhibitors of 11β-hsd1
In this letter, we reported the design and synthesis of three potent, selective, and orally bioavailable 11β-HSD1 inhibitors labeled with 14C: AMG 456 (1), AM-6949 (2), and AM-7715 (3). We evaluated the covalent protein binding of the labeled i
Sun, Daqing,Ye, Qiuping,Yan, Xuelei,Rew, Yosup,Fan, Peter,He, Xiao,Jiang, Min,McMinn, Dustin L.,Monshouwer, Mario,Tu, Hua,Powers, Jay P.
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p. 1245 - 1250
(2015/04/27)
ARYL SULFONES AND USES RELATED THERETO
Aryl sulfone compounds of formula (I) and (II) are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders.
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Page/Page column 77-78
(2010/02/14)
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