Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors
A novel series of non-covalent, benzimidazole-based inhibitors of DPP-4 has been developed from a small fragment hit using structure-based drug design. A highly versatile synthetic route was created for the development of SAR, which led to the discovery o
Wallace, Michael B.,Feng, Jun,Zhang, Zhiyuan,Skene, Robert J.,Shi, Lihong,Caster, Christopher L.,Kassel, Daniel B.,Xu, Rongda,Gwaltney II, Stephen L.
p. 2362 - 2367
(2008/09/20)
Dipeptidyl peptidase inhibitors
Compounds, pharmaceutical compositions, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound of the formula: wherein the substituents are as defined herein.
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Page/Page column 32
(2010/02/14)
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