- Facile and efficient one-pot procedure for thieno[2,3-e][1,2,3]triazolo[1, 5-a]pyrimidines preparation
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Base-catalyzed cycloaddition reactions of heterocyclic azides with activated nitriles were studied. Convenient, efficient, and high-yield synthetic method for thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines preparation from available starting reagents without complicated protocols was elaborated. Such an approach allows creation of broad combinatorial libraries for drug discovery. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]
- Pokhodylo, Nazariy T.,Shyyka, Olga Y.,Obushak, Mykola D.
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p. 1002 - 1006
(2014/03/21)
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- (E-Z) ISOMERIZATION OF UNSATURATED NITRILES
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Equilibrium data of the title isomerization of X-CH=CH-CN nitriles (X=Cl, CN, OR, SR) have been measured , and the respective ΔG values have been compared with the energy difference calculated by the CNDO/2 method.
- Prochazka, Milos,Zaruba, Arno
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