Synthesis, Anti-Inflammatory Activity, and COX-1/2 Inhibition Profile of Some Novel Non-Acidic Polysubstituted Pyrazoles and Pyrano[2,3-c]pyrazoles
The synthesis and evaluation of the anti-inflammatory activity of some structure hybrids comprising basically the 5-hydroxy-3-methyl-1-phenyl-4-substituted-1H-pyrazole scaffold directly linked to a variety of heterocycles and functionalities, or annulated
Faidallah, Hassan M.,Rostom, Sherif A. F.
(2017/05/05)
Synthesis of 4-(Acylacetyl)-1-phenyl-2-pyrazolin-5-ones from 3-Acyl-2H-pyran-2,4(3H)-diones. Their Synthetic Applications to Functionalized 4-Oxopyranopyrazole Derivatives.
The phenylhydrazones of 3-acyl-2H-pyran-2,4(3H)-diones (2), in refluxing acetic acid, underwent rearrangement to 4-(acylacetyl)-1-phenyl-2-pyrazolin-5-ones (6), from which some functionalized 4-oxopyranopyrazole derivatives were synthesized.This fi