- Thiotetrazole alkynylacetanilides as potent and bioavailable non-nucleoside inhibitors of the HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases
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A series of aryl thiotetrazolylacetanilides were synthesized and found to be potent inhibitors of the HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases. The incorporation of an alkynyl fragment on the aniline provided inhibitors with ex
- Gagnon, Alexandre,Amad, Ma'an H.,Bonneau, Pierre R.,Coulombe, Rene,DeRoy, Patrick L.,Doyon, Louise,Duan, Jianmin,Garneau, Michel,Guse, Ingrid,Jakalian, Araz,Jolicoeur, Eric,Landry, Serge,Malenfant, Eric,Simoneau, Bruno,Yoakim, Christiane
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p. 4437 - 4441
(2008/02/11)
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- NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
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The invention relates to compounds of formula (I) wherein Ar, X, R1, R2, R3 and R4 are as defined herein and, pharmaceutical compositions thereof useful, either alone or in combination with other therapeutic agents as reverse transcriptase inhibitors against wild type and single or double mutant strains of HIV for the treatment or prophylaxis of HIV infection
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Page/Page column 83
(2008/06/13)
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