- Oxaspirocyclic Spiro-Substituted Tetramic Acid and Tetronic Acid Derivatives
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The present invention relates to novel oxaspirocyclic spirophenyl-substituted tetramic acid and tetronic acid derivatives of the formula (I) in which W, X, Y, Z, A, B, D, Q1, Q2, and G have the meanings given above, to a plurality of
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Page/Page column 50-51
(2011/11/06)
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- 1- (1-CYCLOHEXYL-4-PIPERIDINYL) -1, 3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES WHICH HAVE ACTIVITY ON THE M1 RECEPTOR AND THEIR USE IN MEDICINE
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Compounds of Formula (I) or a salt thereof are provided: wherein R1, R2, R4, R5, R6, Q and Z are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicamen
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Page/Page column 57-58
(2008/12/04)
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- Certain aryl substituted pyrrolopyrazines; a new class of gaba brain receptor ligands
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This invention encompasses compounds of formula (I) and pharmaceutically acceptable non-toxic salts thereof wherein (Ia) represents (i) or (ii) where n is 0, 1, or 2: R 1 and R 2 are hydrogen or straight or branched chain alkyl groups; Y various organic a
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- CERTAIN ARYL SUBSTITUTED PYRROLOPYRAZINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS
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This invention encompasses compounds of the formula: STR1 and pharmaceutically acceptable non-toxic salts thereof wherein: STR2 represents: STR3 where n is 0, 1, or 2; R 1 and R 2 are hydrogen or straight or branched chain alkyl groups;Y represents
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- Certain cycloalkyl and azacycloalkyl pyrrolopyridines; a new class of gaba rain receptor ligands
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The present invention encompasses compounds of the formula: STR1 and pharmaceutically acceptable non-toxic salts thereof wherein: A represents nitrogen or C--H, andB represents nitrogen or C--H, with the proviso that when A is nitrogen, B is C--H, and whe
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- CERTAIN ARYL SUBSTITUTED PYRROLOPYRAZINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS
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This invention encompasses compounds of the formula: STR1 and pharmaceutically acceptable non-toxic salts thereof wherein: STR2 represents: STR3 where n is 0, 1, or 2; R 1 and R 2 are hydrogen or straight or branched chain alkyl groups;Y represents
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- CERTAIN CYCLOALKYL AND AZACYCLOALKYL PYRROLOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS
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The invention encompasses a compound of the formula STR1 and the pharmaceutically acceptable non-toxic salts thereof wherein X, W, Y, R, and R2 are variables.These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine type drugs, and enhancement of alertness.
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- Analgesic 1-oxa-, aza- and thia-spirocyclic compounds
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Mono-Oxa-, thiaspirocyclic-benzene-acetamide and -benzamide compounds of the formula STR1 wherein p, n, m, A, E, R, R1, R2, X, Y and Z are as defined in the specification, e.g., (±)-(5α,7α,9β)-3,4-dichloro-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]benzeneacetamide, and the pharmacologically acceptable salts thereof, are useful as analgesic compounds having low physical dependence liability, compared to morphine and methodone, and low dysphoria side effects. Some of these compounds have potent analgesic activity when administered orally, and some have low CNS sedative side effects. Pharmaceutical compositions and methods for using these compounds as analgesics are disclosed. Processes for preparing this class of compounds are also disclosed.
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