- A [...][...] synthetic method
-
The invention relates to a synthetic method for gizzerosine and belongs to the technical field of medicines. According to the synthetic method provided by the invention, the steric hindrance of an end amino of lysine is different from that of an alpha-site amino, directly reacts with 4-(2-chloroethyl) imidazole to synthesize a target product through three-step reactions: histamine hydrochloride hydroxylation , chloro reaction and condensation. The method is simple and fast, is suitable for large-scale synthesis, and can be widely applied to related scientific research fields such as toxicology and metabolic experiments.
- -
-
Paragraph 0107; 0108; 0115; 0122
(2018/06/14)
-
- Histaminol and Its Complexes with Copper(II) – Studies in Solid State and Solution
-
Histaminol [4(5)-(β-hydroxyethyl)imidazole, 4-(1H-imidazol-2-yl)ethanol, L] is an analogue of histamine and its minor metabolite. So far its properties have not been studied in detail due to the synthetic difficulties. Here, the structure and acid-base properties of histaminol, as well as the results of studies on its copper(II) complexes in solid state and aqueous solution are reported. Stability constants of the histaminol–CuII system are measured and each stage of the complex formation is illustrated with the relevant crystal structure and the EPR spectrum.
- Ma?lewski, Piotr,Wyrzykowski, Dariusz,Witwicki, Maciej,Do??ga, Anna
-
p. 1399 - 1408
(2018/04/06)
-
- ARYL SUBSTITUTED IMIDAZO [4,5-C] PYRIDINE COMPOUNDS AS C3A RECEPTOR ANTAGONISTS
-
Aryl substituted imidazo[4,5-c] pyridine compounds of formula (I) or pharmaceutically acceptable salt thereof are provided. These compounds are useful in pharmaceutical compositions as C3a antagonists for treating a variety of medical conditions associated with the Complement cascade.
- -
-
Page/Page column 56
(2010/11/26)
-
- Color developing agent, processing composition and color image-forming method
-
A method for forming a color image comprises the step of developing an image-wise exposed silver halide color photographic photosensitive material at the presence of a 6-aminotetrahydroquinoline color developing agent which is the following compound or its analoge. According to this method, the rapid process can be attained and an image of a low fog density can be obtained. STR1
- -
-
-