cas 87269-87-2, (1S,3S,5S)-2-Azabicyclo[3,3,0]octane-3-carborylic acid benzyl ester hydrochloride

Articles about 87269-87-2Total 9 be found

Shape Similarity by Fractal Dimensionality: An Application in the de novo Design of (?)-Englerin A Mimetics
Molecular shape and pharmacological function are interconnected. To capture shape, the fractal dimensionality concept was employed, providing a natural similarity measure for the virtual screening of de novo generated small molecules mimicking the structurally complex natural product (?)-englerin A. Two of the top-ranking designs were synthesized and tested for their ability to modulate transient receptor potential (TRP) cation channels which are cellular targets of (?)-englerin A. Intracellular calcium assays and electrophysiological whole-cell measurements of TRPC4 and TRPM8 channels revealed potent inhibitory effects of one of the computer-generated compounds. Four derivatives of this identified hit compound had comparable effects on TRPC4 and TRPM8. The results of this study corroborate the use of fractal dimensionality as an innovative shape-based molecular representation for molecular scaffold-hopping.
Bauer, Christoph,Byrne, Ryan,Friedrich, Lukas,Gudermann, Thomas,Mederos y Schnitzler, Michael,Schneider, Gisbert,Singh, Inderjeet,Storch, Ursula,Treder, Aaron
supporting information

(2020/03/24)

A METHOD FOR PREPARING RAMIPRIL
Enantio-specific synthesis of optically pure (2S)-acetylamino-3-(2-oxo-cyclopentyl)- propionic acid (I) comprising converting enantiomeric mixture of (1 -4C alkyl)-2- acetylamino-3-(2-oxocyclopentyl) propionoate (II) (+ and -) under the influence of an Alkaline serine endopeptidase is disclosed. The invention further describes use of optically pure (2S)-acetylamino-3-(2-oxocyclopentyl)-propionic acid (I) formed by the process of present invention, in the preparation of Ramipril.
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(2015/04/15)

Asymmetric synthesis of (S,S,S)-2-Aza-bicyclo-[3.3.0]-octane-3-carboxylic acid benzyl ester: Formal synthesis of ramipril
An asymmetric synthesis of (S,S,S)-2-aza-bicyclo-[3.3.0]-octane-3- carboxylic acid benzyl ester 2 as an intermediate of angiotensin converting enzyme (ACE) inhibitor, ramipril 1, is described.
Kondaiah,Vivekanandareddy,Reddy, L. Amarnath,Anurkar, Smita V.,Gurav,Ravikumar,Bhattacharya, Apurba,Bandichhor, Rakeshwar
p. 1186 - 1191
(2011/05/05)

A PROCESS FOR PREPARATION OF RAMIPRIL
Disclosed herein is a process for preparation of Ramipril; which comprises; reacting salts of (S,S,S)-azabicyclo[3.3.0]-octane-3-carboxylate with N-[l-(S)-ethoxy carbonyl)-3- phenyl propyl] -L-alanine in presence of dicyclohexylcarbodimide (DCC) and 1- hydroxybenzotriazole (HOBT) in a suitable solvent medium.
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Page/Page column 12

(2009/10/30)

METHOD FOR THE PRODUCTION OF RAMIPRIL
An improved method for preparing ramipril is disclosed, and also an intermediate for use in the method.
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Page/Page column 6

(2009/01/24)

PREPARATION OF RAMIPRIL AND STABLE PHARMACEUTICAL COMPOSITIONS
A process for preparing ramipril, and stable pharmaceutical compositions containing ramipril.
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Page/Page column 11

(2010/11/28)

SYNTHESIS OF UNNATURAL AMINO ACIDS: (S,S,S)-2-AZABICYCLOOCTANE-3-CARBOXYLIC ACID
(S,S,S)-2-Azabicyclooctane-3-carboxylic acid 1, a structural element of the very potent ACE inhibitor HOE 498, is readily available via a diastereo selective synthesis starting from serine or cystine.
Teetz, V.,Geiger, R.,Gaul, H.
p. 4479 - 4482
(2007/10/02)

Synthesis of a highly active angiotensin converting enzyme inhibitor: 2-[N-[(S)-1-ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-(1S,3S,5S)-2-azabicyc lo[3.3.0]octane-3-carboxylic acid (Hoe 498)
The convergent, diastereoselective synthesis of 2-[N-[(S)-1-ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-(1S,3S,5S)-2-azabicyc lo[3.3.0]octane-3-carboxylic acid (Hoe 498), a new ACE-inhibitor with improved bioavailability and pharmacokinetics, is described.
Teetz,Geiger,Henning,Urbach
p. 1399 - 1401
(2007/10/02)