- Efficient and regioselective functionalization of imidazo[1,2-b]pyridazines via palladium-catalyzed cross-coupling reaction and SNAr
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The synthesis of 3,6-disubstituted-2-phenylimidazo[1,2-b]pyridazine derivatives by palladium cross-coupling and SNAr reactions is described. Sonogashira and Stille cross-coupling reactions were investigated to introduce alkynyl, alkenyl, and ar
- El Akkaoui,Koubachi,El Kazzouli,Berteina-Raboin,Mouaddib,Guillaumet
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p. 2472 - 2475
(2008/09/20)
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- FUSED HETEROCYCLES AS LCK INHIBITORS
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There is provided fused heterocycles of imidazopyridazine or pyrazolopyrimidine derivative represented by the formula (I), which have excellent Lck inhibitory activity and are useful for a medicament particularly an immunosuppressive agent. [wherein one of Y and Z is C atom, and the other is N atom; -X-10 is -N (R1) - or the like, -R1 is hydrogen or the like, -A- is bond or the like, is cycloalkyl, aryl or the like, -E- is bond or the like, -R3 is aryl, aromatic heterocycle or the like, -R4, -R5 and -R6 are the same or different, each being hydrogen or the like.]
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Page/Page column 32
(2010/11/25)
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- New calcineurin inhibiting 3-dimethylaminopropyl substituted diarylheterocycles by sonogashira reactions and catalytic hydrogenation
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A series of calcineurin inhibiting compounds 1 consisting of a central aromatic N-heterocycle, two aryl substituents and a 3-dimethylaminopropyl chain was synthesized by introduction of the side chain. A corresponding haloheterocycle 3 was transformed int
- Yin, Lunxiang,Erdmann, Frank,Liebscher, Juergen
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p. 1369 - 1379
(2007/10/03)
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