- An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites
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The emergence of artemisinin-resistant Plasmodium falciparum malaria in Southeast Asia has reinforced the urgent need to discover novel chemotherapeutic strategies to treat and control malaria. To address this problem, we prepared a set of dual-acting tet
- Oliveira, Rudi,Newton, Ana S.,Guedes, Rita C.,Miranda, Daniela,Amewu, Richard K.,Srivastava, Abhishek,Gut, Jiri,Rosenthal, Philip J.,O'Neill, Paul M.,Ward, Stephen A.,Lopes, Francisca,Moreira, Rui
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Read Online
- 4-Oxocyclohexanecarboxylic acid: Hydrogen bonding in the monohydrate of a δ-keto acid
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The title monohydrate, C7H10O 3·H2O, aggregates as a complex hydrogen-bonding network, in which the water molecule accepts a hydrogen bond from the carboxyl group of one molecule and donates hydrogen bonds to ketone and carboxyl C=O functions in two additional molecules, yielding a sheet-like structure of parallel ribbons. The keto acid adopts a chiral conformation through rotation of the carboxyl group by 62.50 (15)° relative to the plane defined by its point of attachment and the ketone C and O atoms. Two C - H=O close contacts exist in the structure.
- Barcon, Alan,Brunskill, Andrew P.J.,Thompson, Hugh W.,Lalancette, Roger A.
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Read Online
- TGF-betaR1 inhibitor and application thereof
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The invention belongs to the field of medical chemistry, and particularly relates to a compound serving as a TGF-betaR1 inhibitor and application of the compound. Specifically, the invention providesa compound shown as a formula I or an isomer, a pharmaceutically acceptable salt, a solvate, a crystal or a prodrug thereof, a preparation method of the compounds, a pharmaceutical composition containing the compounds and application of the compounds or the composition to treatment and/or prevention of TGF-betaR1 related diseases, such as cancers, tissue hyperplasia diseases, fibrosis and inflammatory diseases. The compound provided by the invention shows significant inhibitory activity on TGF-betaR1 kinase, and is very expected to become a therapeutic agent for TGF-betaR1 related diseases.
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Paragraph 1061; 1063-1065
(2020/06/09)
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- BETUIN DERIVATIVES FOR PREVENTING OR TREATING HIV INFECTIONS
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The present invention relates to compounds characterized by having a structure according to the following Formula I, or a pharmaceutically acceptable salt thereof. Compounds of the present invention are useful for the treatment or prevention of HIV.
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Paragraph 00214
(2017/02/24)
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- COMPOUNDS WITH HIV MATURATION INHIBITORY ACTIVITY
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The present invention relates to compounds characterized by having a structure according to the following Formula (I), or a pharmaceutically acceptable salt thereof. Compounds of the present invention are useful for the treatment or prevention of HIV.
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Paragraph 00216
(2017/04/11)
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- Epsilon-caprolactone derivatives and preparation method and application thereof
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The invention relates to the field of biomedical materials, and concretely relates to novel water-soluble epsilon-caprolactone derivatives for preparing biomedical polymer materials with biodegradability, wherein the structural formula of the derivatives
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Paragraph 0040; 0041
(2017/11/16)
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- NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES
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The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes: (I). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.
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Page/Page column 73; 223
(2016/06/28)
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- BENZOTHIAZOLE DERIVATIVES AND A USE THEREOF FOR THE TREATMENT OF CANCER
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Provided are a compound represented by Formula I, a pharmaceutically acceptable salt thereof, or a solvate thereof; and a pharmaceutical composition for cancer treatment and a pharmaceutical composition for a radiation sensitizer for cancer treatment, eac
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Paragraph 0088; 0089; 0090
(2016/02/18)
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- Photoinduced Oxidation of Secondary Alcohols Using 4-Benzoylpyridine as an Oxidant
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Photoinduced oxidation of secondary alcohols to ketones was achieved by utilizing an equimolar amount of 4-benzoylpyridine as an oxidant. This transformation proceeds at ambient temperature and exhibits high compatibility with polar functionalities including benzoyl, silyl, and methoxymethyl alcohol protecting groups as well as tosyloxy, bromo, sulfonyl, carbamate, ester, and carboxylic acid units. The present oxidation is solely promoted by the action of organic molecules without the aid of metallic reagents. (Chemical Equation Presented).
- Kamijo, Shin,Tao, Keisuke,Takao, Go,Tonoda, Hiroshi,Murafuji, Toshihiro
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supporting information
p. 3326 - 3329
(2015/07/15)
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- Discovery of 6-phenylpyrimido[4,5- B ][1,4]oxazines as potent and selective Acyl CoA: Diacylglycerol acyltransferase 1 (DGAT1) inhibitors with in vivo efficacy in rodents
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The discovery and optimization of a series of acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors based on a pyrimido[4,5-b][1,4]oxazine scaffold is described. The SAR of a moderately potent HTS hit was investigated resulting in the discovery of phenylcyclohexylacetic acid 1, which displayed good DGAT1 inhibitory activity, selectivity, and PK properties. During preclinical toxicity studies a metabolite of 1 was observed that was responsible for elevating the levels of liver enzymes ALT and AST. Subsequently, analogues were synthesized to preclude the formation of the toxic metabolite. This effort resulted in the discovery of spiroindane 42, which displayed significantly improved DGAT1 inhibition compared to 1. Spiroindane 42 was well tolerated in rodents in vivo, demonstrated efficacy in an oral triglyceride uptake study in mice, and had an acceptable safety profile in preclinical toxicity studies.
- Fox, Brian M.,Sugimoto, Kazuyuki,Iio, Kiyosei,Yoshida, Atsuhito,Zhang, Jian,Li, Kexue,Hao, Xiaolin,Labelle, Marc,Smith, Marie-Louise,Rubenstein, Steven M.,Ye, Guosen,McMinn, Dustin,Jackson, Simon,Choi, Rebekah,Shan, Bei,Ma, Ji,Miao, Shichang,Matsui, Takuya,Ogawa, Nobuya,Suzuki, Masahiro,Kobayashi, Akio,Ozeki, Hidekazu,Okuma, Chihiro,Ishii, Yukihito,Tomimoto, Daisuke,Furakawa, Noboru,Tanaka, Masahiro,Matsushita, Mutsuyoshi,Takahashi, Mitsuru,Inaba, Takashi,Sagawa, Shoichi,Kayser, Frank
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supporting information
p. 3464 - 3483
(2014/05/20)
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- CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS
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Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
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Page/Page column 149; 150
(2014/10/03)
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- NOVEL ARYLALKENE DERIVATIVES AND USE THEREOF AS SELECTIVE ESTROGEN RECEPTOR MODULATORS
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The invention provides novel ethylene derivatives represented by Formula I, which may be used as selective estrogen receptor modulators (SERMs) and useful in the prophylaxis and/or treatment of estrogen-dependent conditions or conditions.
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Paragraph 0219
(2013/07/19)
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- IMIDAZOTHIADIAZOLE AND IMIDAZOPYRAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION
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The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R5, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.
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Paragraph 00381
(2013/11/18)
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- HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS
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The present invention relates to heterocyclic compounds of formula 1, in all their stereoisomeric and tautomeric forms; and their pharmaceutically acceptable salts, solvates, polymorphs, prodrugs, carboxylic acid isosteres and N-oxides. The invention also relates to processes for the manufacture of the heterocyclic compounds and to pharmaceutical compositions containing them. The said compounds and their pharmaceutical compositions are useful in the prevention and treatment of diseases or disorders mediated by diacylglycerol acyltransferase (DGAT), particularly DGAT1. The present invention further provides a method of treatment of such diseases or disorders by administering a therapeutically effective amount of said compounds or their pharmaceutical compositions, to a mammal in need thereof.
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- Structure-activity relationships of cycloalkylamide derivatives as inhibitors of the soluble epoxide hydrolase
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Structure-activity relationships of cycloalkylamide compounds as inhibitors of human sEH were investigated. When the left side of amide function was modified by a variety of cycloalkanes, at least a C6 like cyclohexane was necessary to yield reasonable inhibition potency on the target enzyme. In compounds with a smaller cycloalkane or with a polar group on the left side of amide function, no inhibition was observed. On the other hand, increased hydrophobicity dramatically improved inhibition potency. Especially, a tetrahydronaphthalene (20) effectively increased the potency. When a series of alkyl or aryl derivatives of cycloalkylamide were investigated to continuously optimize the right side of the amide pharmacophore, a benzyl moiety functionalized with a polar group produced highly potent inhibition. A nonsubstituted benzyl, alkyl, aryl, or biaryl structure present on the right side of the cycloalkylamide function induced a big decrease in inhibition potency. Also, the resulting potent cycloalkylamide (32) showed reasonable physical properties.
- Kim, In-Hae,Park, Yong-Kyu,Hammock, Bruce D.,Nishi, Kosuke
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experimental part
p. 1752 - 1761
(2011/05/05)
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- Degradation of a model naphthenic acid, cyclohexanoic acid, by vacuum UV (172 nm) and UV (254 nm)/H2O2
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The mechanism of hydroxyl radical initiated degradation of a typical oil sands process water (OSPW) alicyclic carboxylic acid was studied using cyclohexanoic acid (CHA) as a model compound. By use of vacuum ultraviolet irradiation (VUV, 172 nm) and ultraviolet irradiation in the presence of hydrogen peroxide UV(254 nm)/H2O2, it was established that CHA undergoes degradation through a peroxyl radical. In both processes the decay of the peroxyl radical leads predominantly to the formation of 4-oxo-CHA, and minor amounts of hydroxy-CHA (detected only in UV/H2O 2). In UV/H2O2, additional 4-oxo-CHA may also have been formed by direct reaction of the oxyl radical with H-O 2. The oxyl radical can be formed during decay of the peroxyl-CHA radical or reaction of hydroxy-CHA with hydroxyl radical. Oxo- and hydroxy-CHA further degraded to various dihydroxy-CHAs. Scission of the cyclohexane ring was also observed, on the basis of the observation of acyclic byproducts including heptadioic acid and various short-chain carboxylic acids. Overall, the hydroxyl radical induced degradation of CHA proceeded through several steps, involving more than one hydroxyl radical reaction, thus efficiency of the UV/H 2O2 reaction will depend on the rate of generation of hydroxyl radical throughout the process. In real applications to OSPW, concentrations of H2O2 will need to be carefully optimized and the environmental fate and effects of the various degradation products of naphthenic acids considered.
- Drzewicz, Przemyslaw,Afzal, Atefeh,El-Din, Mohamed Gamal,Martin, Jonathan W.
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experimental part
p. 12067 - 12074
(2011/02/27)
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- Compounds Which Modulate The CB2 Receptor
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Compounds of formula (I) are disclosed. Compounds according to the and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
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Page/Page column 73
(2010/02/17)
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- 2,3,4,9- TETRAHYDRO-1H-CARBAZOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS
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The invention relates to novel tetrahydro-1H-carbazole derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and methods of treatment comprising administration of said compounds to patients.
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Page/Page column 16
(2009/10/31)
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- OXOPIPERIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF
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The present invention relates to compounds of formula (I) as defined herein that are melanocortin receptor agonists, to the preparation thereof and to the therapeutic use thereof in the treatment or prevention of a condition selected from obesity, diabetes and sexual dysfunctions that can affect both sexes, in the treatment of cardiovascular diseases, and also in anti-inflammatory uses or in the treatment of alcohol dependency.
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Page/Page column 31
(2010/11/27)
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- 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds
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4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lowe
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Page/Page column 44
(2010/10/20)
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- 2,3,4,9-TETRAHYDRO-1H-CARBAZOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS
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The invention relates to novel tetrahydro-lH-carbazole derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and methods of treatment comprising administration of said compounds to patients.
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Page/Page column 44
(2008/06/13)
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- Efficient synthesis of a new pipecolic acid analogue with a bicyclic structure
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This report describes the synthesis of 2-azabicyclo[2.2.2]octane-1-carboxylic acid, a constrained pipecolic acid analogue. The route gives a very good total yield starting from cheap and readily available compounds and uses very easy reactions.
- Casabona, Diego,Cativiela, Carlos
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p. 10000 - 10004
(2007/10/03)
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- Oligo(cyclohexylidene)s and oligo(cyclohexyl) as bridges for photoinduced intramolecular charge separation and recombination
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A series of semirigid donor-bridge-acceptor (D-B-A) molecules was synthesized to study the effect of the position and number of nonconjugated olefinic bonds in the bridge on the photoinduced charge-separation and charge-recombination kinetics. The molecules consist of a phenylpiperidine electron donor, an oligo-(cyclohexylidene) or oligo(cyclohexyl) bridge, and a dicyanovinyl acceptor. Partly saturated ter(cyclohexylidene) bridges were used as well. The edge-to-edge donor-acceptor separation of the compounds under study varies between 2.89 and 15.4 A. The replacement of a C-C single bond by an olefinic bond increases the rate of charge separation with a factor of 3.0 ± 0.8 per replaced bond. For all D-B-A compounds the extended fully charge-separated state folds to a compact charge-transfer (CCT) conformer. The rate of charge recombination (CR) of the CCT state increases with solvent polarity for those compounds having an olefinic bond located three σ bonds from the acceptor. Thus, while in cyclohexane the CR rate is equal for all compounds, in benzene the CR rate in compounds with an olefinic bond near the acceptor is 10 times larger than in compounds with a single bond instead. It is believed that a (virtual) charge-transfer state involving the radical cation of the olefinic bond and the radical anion of the acceptor (D-B;+-A-) is responsible for the enhanced CR process.
- Oosterbaan, Wibren D.,Koper, Carola,Braam, Thijs W.,Hoogesteger, Frans J.,Piet, Jacob J.,Jansen, Bart A. J.,Van Walree, Cornelis A.,Van Ramesdonk, H. Johan,Goes, Marijn,Verhoeven, Jan W.,Schuddeboom, Wouter,Warman, John M.,Jenneskens, Leonardus W.
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p. 3612 - 3624
(2007/10/03)
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- Tetrahydrocarbazol derivatives as ligands for G-protein-coupled receptors (GPCR)
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This invention provides new tetrahydrocarbazole derivatives that act as ligands for G-protein-coupled receptors (GPCR), especially as antagonists of the gonadotropin-releasing hormone (GnRH). A pharmaceutical composition that contains these new tetrahydro
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- Spiro and dispiro 1,2,4-trioxolane antimalarials
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A means and method for treating malaria using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl or spiropiperidyl ring on the other side of the trioxolane group, whereby the spirocyclohexyl ring is preferably functionalized or substituted at the 4-position or a spiropiperidyl ring that is functionalized or substituted at the nitrogen atom. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.
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- Design and synthesis of non-peptidic inhibitors for the Syk C-terminal SH2 domain based on structure-based in-silico screening
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Structure-based in-silico screening was carried out for the Syk C-terminal SH2 domain. Fragments that could interact with the pY or pY+1 pockets were selected by our in-silico screening. After tethering two fragments bound to these pockets, we have designed and synthesized new compounds that show favorable interaction with the pY+3 pocket. One such compound, having a cyclohexylmalonic acid moiety identified as a novel potent phosphotyrosyl mimetic, exhibited an affinity comparable to that of the monophosphorylated ligand peptide.
- Niimi,Orita,Okazawa-Igarashi,Sakashita,Kikuchi,Ball,Ichikawa,Yamagiwa,Sakamoto,Tanaka,Tsukamoto,Fujita
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p. 4737 - 4740
(2007/10/03)
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- Fibrinogen receptor antagonists
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This invention relates to compounds of the formula: which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.
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- ALKENYL COMPOUNDS BEARING OXYGENIC LINKAGES, LIQUID-CRYSTAL COMPOSITION, AND LIQUID-CRYSTAL DISPLAY ELEMENT
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Liquid-crystal compounds represented by general formula (1) (wherein X1, X2and X3are each - CH2O-, -OCH2-, -(CH2)3O-, -O(CH2)3-, a covalent bond, -CF2O-, -OCF2-, -CH=CH-, -C≡C-, -CH2CH2-, -(CH2)4-, -CH=CH-CH2CH2- or -CH2CH2-CH=CH-, with the proviso that at least one of them is -CH2O-, -OCH2-, -(CH2)3O- or -O(CH2)3-; R1is C2-C20alkenyl; Y1is halogeno, cyano or substituted or unsubstituted C1-C20alkyl; the rings A1, A2, A3and A4are each substituted or unsubstituted 1,4-cyclohexylene, 1,4-cyclohexenylene or 1,4-phenylene; and m and n are each 0 or 1); and a liquid-crystal composition and a liquid-crystal display element containing at least one of these compounds. The compounds exhibit steep threshold value characteristics, an excellent compatibility, a low viscosity, a quick response, and so on.
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- Aminopyrimidines with high affinity for both serotonin and dopamine receptors
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A series of {4-[2-(4-arylpiperazin-1-yl)alkyl]cyclohexyl}pyrimidin-2- ylamines was prepared and found to have receptor binding affinity for D2 and D3 dopamine (DA) receptors and serotonin 5-HT1A receptors. The structural contributions to D2/D3 and 5-HT1A
- Wustrow, David,Belliotti, Thomas,Glase, Shelly,Kesten, Suzanne Ross,Johnson, Don,Colbry, Norman,Rubin, Ronald,Blackburn, Anthony,Akunne, Hyacinth,Corbin, Ann,Duff Davis,Georgic, Lynn,Whetzel, Steven,Zoski, Kim,Heffner, Thomas,Pugsley, Thomas,Wise, Lawrence
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p. 760 - 771
(2007/10/03)
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- Heterocyclylamino-and heterocyclyloxy-cycloalkyl derivatives, their preparation, and their use as pesticides and fungicides
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Heterocyclylamino- and heterocyclyloxy-cycloalkyl derivatives, their preparation, and their use as pesticides and fungicides STR1 in which Ar is optionally substituted 4-pyridyl or 4-pyrimidinyl; X is NH, O or S; E is a bond or alkanediyl; n is 2-7; R4 is H or alkyl, Y is O or a bond; and Ac is acyl, and salts thereof. The invention furthermore relates to processes for their preparation, to compositions comprising them, and to their use as pesticides and fungicides.
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- Potentiating effects of β-eudesmol-related cyclohexylidene derivatives on succinylcholine-induced neuromuscular block in isolated phrenic nerve-diaphragm muscles of normal and alloxan-diabetic mice
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β-Eudesmol, a sesquiterpenoid alcohol contained in Atractylodes lancea, potentiates succinylcholine (SuCh)-induced neuromuscular blockade. The potentiating effect is greater in diabetic muscles than in normal ones. As a ligand for affinity chromatography to study the potentiating mechanism, we designed and synthesized newly β-eudesmol-related cyclohexylidene derivatives (2-(3-hydroxy-3-methylbutyl)cyclohexylidene KTE-13, 2-(3-hydroxy-3-methylbutyl)-4-cyclohexyl carboxylic acid; KTE-32 and 4-tert-butoxycarbonyl-2- (3-hydroxy-3-methylbutyl) cyclohexylidene; KTE-33). We examined the potentiating effects of those compounds in phrenic nerve-diaphragm muscle preparations of normal and alloxan-diabetic mice. KTE-33 (100 μM) potentiated more greatly SuCh-induced neuromuscular blockade in diabetic muscles than in normal ones (the potentiating ratios in normal and diabetic muscles were 6.7 and 10.6, respectively), while KTE-13 (100 μM) and -32 (200 μM) potentiated weakly. These results suggest that the ester group in KTE-33 rather than a carboxyl group in KTE-32 is important in inducing the potentiation of SuCh-induced neuromuscular blockade in diabetic state.
- Kimura,Diwan,Yanagi,Kon-No,Nojima,Kimura
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p. 407 - 410
(2007/10/03)
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- Fluorescence Studies with Tryptophan Analogues: Excited State Interactions Involving the Side Chain Amino Group
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The fluorescence of a large set of tryptophan analogues, including several that are conformationally constrained, was studied.The constrained analogues include tetrahydrocarboline-3-carboxylic acid and 3-amino-3-carboxytetrahydrocarbazole.Steady state and time-resolved fluorescence measurements were made as a function of pH.The fluorescence quantum yields of the constrained analogues are higher than those for the unconstrained counterparts.The emission intensity of the constrained analogues, as well as 4-methyltryptophan, decreases with deprotonation of the side chain α-ammonium groups; this is in contrast to the increase in fluorescence of tryptophan with deprotonation of this group.These results are consistent with the existence of excited state proton transfer to carbon 4 of the indole ring as a quenching mechanism, which is sterically prohibited in the constrained analogues and 4-methyltryptophan.From quantum yield and lifetime data (most decays are nonexponential), the effective rate constant for nonradiative depopulation of the excited state was calculated.For tryptophan analogues having two side chain functional groups, there is a synergistic effect; the presence of two side chain groups causes more quenching than expected from the sum of the individual contributions.For analogues having an α-ammonium group, this synergism appears to be correlated with an induced change in the pKa of this group.Deprotonation of this α-ammonium group also caused a red shift in the emission of these compounds; this appears to be due to electrostatic repulsion between the α-NH3+ group and the excited indole dipole.
- Eftink, Maurice R.,Jia, Yiwei,Hu, Dana,Ghiron, Camillo, A.
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p. 5713 - 5723
(2007/10/02)
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- Process for the preparation of 4'-hydroxybiphenyl-4-carboxyl acid
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A process for the preparation of 4'-hydroxybiphenyl-4-carboxylic acid by reacting a cyclohexanone-4-carboxylic acid compound with phenol in the presence of an acid catalyst, and then subjecting the resulting 4,4-bis(4-hydroxyphenyl)cyclohexanecarboxylic acid compound to decomposition and dehydrogenation reactions in the presence of a base and a dehydrogenation catalyst. The aforesaid cyclohexanone-4-carboxylic acid compound is obtained by catalytically hydrogenating a 4-hydroxybenzoic acid compound in a secondary alcohol or tertiary alcohol solvent, and the reaction mixture thus obtained is directly used for the reaction with phenol.
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- 4,4-bis(4-hydroxyphenyl)cyclohexanecarboxylic acid derivatives and process for preparing same
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Novel 4,4-bis(4-hydroxyphenyl)cyclohexanecarboxylic acid derivatives. These compounds can be prepared by reacting a cyclohexanone-4-carboxylic acid with a phenol.
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- SUBSTITUENT EFFECTS ON IONIZATION ENERGIES IN SOME 4R-SUBSTITUTED CYCLOHEXANONES
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A series of 4R-substituted cyclohexanones were investigated by gase-phase UV photoelectron spectroscopy in order to study the influence of the substituent in the ionization energy of the carbonyl non-bonding orbital.A plot of the IEs vs. the su
- Cauletti, Carla,Di Maio, Giorgio,Li, Weimin,Vecchi, Elisabetta,Vondrak, Tomas
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p. 3677 - 3682
(2007/10/02)
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- Synthetic Studies in Carbocyclic Systems : Part I - A new Synthesis of Nopinone
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Base-induced intramolecular nucleophilic displacement of the tosyloxy group of 4-isopropyl-7-tosyloxycyclohexanone affords nopinone , identical with an authentic specimen.
- Murthi, G. S. S.,Mazumder, Alok
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p. 339 - 340
(2007/10/02)
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