- Preparation method of 5-(2-bromoethyl)pyrimidine
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The invention discloses a preparation method of 5-(2-bromoethyl) pyrimidine, and belongs to the field of medicinal chemistry. 5-acetaldehydeyl-4,6-dichloropyrimidine, sodium borohydride and thionyl bromide which are used as raw materials undergo a three-step reaction under the action of a catalyst Pd/C to obtain the target product 5-(2-bromoethyl)pyrimidine. The method has the advantages of simplicity in operation, mild reaction conditions, and environmental friendliness, makes the comprehensive yield reach 80% or above, and is suitable for industrial large-scale production.
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- IMIDAZOTRIAZINONE COMPOUNDS
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The present invention provides imidazotriazinone compounds which are inhibitors of phosphodiesterase 9 and pharmaceutically acceptable salt thereof. The present invention further provides processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of PDE9 associated diseases or disorders in mammals, including humans.
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Paragraph 0712; 0713; 0714
(2013/10/08)
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- IMIDAZOLE DERIVATIVES AS IDO INHIBITORS
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Presently provided are IDO inhibitors of general formulae (VII), (VIII) as shown below and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease.
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Page/Page column 158
(2011/06/11)
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