Water-soluble prodrugs of the human immunodeficiency virus protease inhibitors lopinavir and ritonavir
We studied the synthesis, cleavage rates, and oral administration of prodrugs of the HIV protease inhibitors (PIs) lopinavir and ritonavir. Phosphate esters attached directly to the central hydroxyl groups of these PIs did not demonstrate enzyme-mediated
Degoey, David A.,Grampovnik, David J.,Flosi, William J.,Marsh, Kennan C.,Wang, Xiu C.,Klein, Larry L.,McDaniel, Keith F.,Liu, Yaya,Long, Michelle A.,Kati, Warren M.,Molla, Akhteruzzaman,Kempf, Dale J.
experimental part
p. 2964 - 2970
(2010/02/28)
PRODRUGS OF HIV PROTEASE INHIBITORS
A compound of the formula , or is disclosed as a prodrug of an HIV protease inhibitor. Methods and compositions or inhibiting HIV protease activity and treating HIV infection are also disclosed.
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Page/Page column 74
(2010/10/19)
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