NOVEL THIOPHENE DERIVATIVES AS IMMUNOSUPPRESSIVE AGENTS
The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.
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(2010/02/15)
NOVEL THIOPHENE DERIVATIVES
The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.
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(2010/02/15)
Sulfonamide derivatives for the treatment of diseases
The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in
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(2008/06/13)
Selective copper(II)-mediated oxidative coupling of a nucleophilic reagent to the para-methyl group of 2,4,6-trimethylphenol
A copper(II) neocuproine system has been developed for the efficient and very selective 1,6-addition of a nucleophile to the para-methyl group of 2,4,6-trimethylphenol. Crystallographic and spectroscopic data point towards the involvement of a μ-methoxo-μ-phenoxo-bridged copper species which appears to generate a highly reactive quinone methide intermediate that can be attacked by a nucleophilic reagent. The Royal Society of Chemistry 2005.
Boldron, Christophe,Oezalp-Yaman, Seniz,Gamez, Patrick,Tooke, Duncan M.,Spek, Anthony L.,Reedijk, Jan