Mild synthesis of asymmetric 2′-carboxyethyl-substituted fluoresceins
(Chemical Equation Presented) Asymmetric fluoresceins bearing a carboxyethyl group in the chromophoric portion of the dyes were prepared by a reaction of substituted phthalic anhydride with a carboxyethyl substituted resorcinol analogue followed by a condensation with a second resorcinol analogue. In order to avoid an accumulation of symmetric side products, the second step was performed in two substeps: acid-catalyzed formation of a triphenylmethyl intermediate followed by base-catalyzed cyclization which furnished the desired dyes.
Lukhtanov, Eugeny A.,Vorobiev, Alexei V.
p. 2424 - 2427
(2008/09/19)
COMPOUNDS AND METHODS FOR FLUORESCENT LABELING
Dye reagents useful in labeling biological materials are provided along with methods for their use.
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(2008/06/13)
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