Synthesis of pyrido[2,1- b ]quinazolin-11-ones and dipyrido[1,2-a:2′,3′- d ]pyrimidin-5-ones by Pd/DIBPP-catalyzed dearomatizing carbonylation
N-Fused heterocycles can be easily synthesized by palladium-catalyzed dearomatizing carbonylation using 1,3-bis(diisobutylphosphino)propane (DIBPP) as the ligand. Pyrido[2,1-b]quinazolin-11-ones were obtained from N-(2-bromophenyl)pyridine-2-amines in up to quantitative yield and dipyrido[1,2-a:2′,3′-d]pyrimidin-5-ones from 3-bromo-N-(pyridine-2-yl)pyridine-2-amines in up to 84% yield. The cyclocarbonylation can be also realized without isolation of compound 1 and additional palladium catalyst.
Xu, Tongyu,Alper, Howard
supporting information
p. 1569 - 1572
(2015/03/30)
Synthesis and anti-HCV activity evaluation of anilinoquinoline derivatives
Hepatitis C virus (HCV) infection is a main cause of chronic liver disease, leading to liver cirrhosis and hepatocellular carcinoma (HCC). The objective of our research was to develop effective agents against viral replication. Here, we have synthesized a
Palladium-catalyzed intramolecular N-arylation of heteroarenes: A novel and efficient route to benzimidazo[1,2-a]quinolines
An efficient new route for the synthesis of benzimidazo-1,2-a]quinolines has been developed via the palladium-catalyzed intramolecular Buchwald-Harwtig aryl amination of newly synthesized 2-(2′-bromoanilino)quinolines.
Venkatesh,Sundaram,Ila,Junjappa
p. 1280 - 1283
(2007/10/03)
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