Synthesis and DABCO-induced demethylation of 3-cyano-4-methoxy-2-pyridone derivatives
An efficient method for synthesis and demethylation of 3-cyano-4-methoxy-2-pyridone derivatives has been developed. DABCO-induced demethylation can lead to 3-cyano-4-hydroxy-2-pyridones in DMF at 90°C with high yield. The protocol is applicable for the synthesis of 3-cyano-4-hydroxy-2-pyridone derivatives. The method is simple, efficient, and practical.
A 'Classical' Approach to the Synthesis of Perloline
An approach to the synthesis of perloline by the reaction of (2-bromophenyl)(3',4'-dimethoxyphenyl)amine with a suitably 4-substituted 2-oxo-1,2-dihydropyridine-3-carboxylic acid was unsuccessful due to the inability to form the amide bond.The diphenylamine was efficiently synthesized from the nitrone of dimethoxybenzylidene-2-bromoaniline via the oxaziridine, the thermal rearrangement of which was investigated.Conjugate additions of a diphenylamine dianion to unsaturated esters are reported.
Kasum, Bruno,Prager, Rolf H.
p. 1455 - 1467
(2007/10/02)
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