- Design of LFA-1 antagonists based on a 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold
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A new class of lymphocyte function-associated antigen-1 (LFA-1) antagonists is described. Elaboration of the 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold resulted in the synthesis of potent inhibitors of the LFA-1/ICAM-1 interaction. Along with the in vi
- Dodd, Dharmpal S.,Sheriff, Steven,Chang, ChiehYing J.,Stetsko, Dawn K.,Phillips, Linda M.,Zhang, Yingru,Launay, Michele,Potin, Dominique,Vaccaro, Wayne,Poss, Michael A.,McKinnon, Murray,Barrish, Joel C.,Suchard, Suzanne J.,Murali Dhar
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p. 1908 - 1911
(2007/10/03)
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- Pyrrolizine compounds useful as anti-inflammatory agents
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Pyrrolizine compounds having the formula (I), or pharmaceutically-acceptable salts thereof, are effective in treating inflammatory or immune diseases, where A is a four- to seven-membered saturated ring, K is O or S, and R1, R2, Rsu
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Page/Page column 19-20
(2010/10/20)
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