- Molecular structures of protonated and mercurated derivatives of thimerosal
-
The carboxylate oxygen of thimerosal, [(ArCO2)SHgEt] Na, is subject to facile electrophilic attack by H+ and [HgEt] + to give (ArCO2H)SHgEt and [(Ar CO2HgEt)SHgEt]sub
- Sattler, Wesley,Yurkerwich, Kevin,Parkin, Gerard
-
-
Read Online
- Hg-C bond protonolysis by a functional model of bacterial enzyme organomercurial lyase MerB
-
Herein, we report a novel synthetic compound 1, having a highly nucleophilic selenolate (Se-) moiety and a thiol (-SH) functional group, which showed efficient Hg-C bond protonolysis of various R-Hg-X molecules including neurotoxic methylmercury and thimerosal, via direct -SH proton transfer to the highly activated C-atom of a departed R group with low activation energy barrier at room temperature (21 °C), in the absence of any external proton source and, thus, acts as a functional model of MerB. This journal is
- Karri, Ramesh,Das, Ranajit,Rai, Rakesh Kumar,Gopalakrishnan, Anaswara,Roy, Gouriprasanna
-
supporting information
p. 9280 - 9283
(2020/10/02)
-
- LIPOXYGENASE-INHIBITING COMPOUNDS DERIVED FROM NON-STEROIDAL ANTIINFLAMMATORY CARBOXYLIC ACIDS
-
Compounds of the formula: STR1 wherein R1 is selected from (1) hydrogen; (2) --NR2 R3, --OR2 or --SR2 where R2 and R3 are independently selected from hydrogen, alkyl, aryl and alkylaryl; and (3) optionally substituted C1-C8 alkyl, C2-C8 alkenyl, arylalkyl
- -
-
-