- Selective Light-Driven Chemoenzymatic Trifluoromethylation/Hydroxylation of Substituted Arenes
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The merging of photoredox trifluoromethylation with hybrid P450 BM3 variants has enabled the selective light-driven functionalization of several arenes. This approach capitalizes on the unique photochemical properties of the Ru(II)-diimine photosensitizer
- Sosa, Victor,Melkie, Marya,Sulca, Carolina,Li, Jennifer,Tang, Lawrence,Li, Jeffrey,Faris, Justin,Foley, Bridget,Banh, Tam,Kato, Mallory,Cheruzel, Lionel E.
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- Resourceful treatment method for industrial wastewater generated in production of 5-chloro-2-nitrobenzotrifluoride
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The invention provides a resourceful treatment method for industrial wastewater generated in production of 5-chloro-2-nitrobenzotrifluoride. The method is mild in condition, simple to operate and high in safety. The method comprises the following steps: feeding wastewater generated in the production of 5-chloro-2-nitrobenzotrifluoride and FSBA into a container, wherein the feeding mass ratio of the wastewater to the FSBA is 1: (0.5-2); reacting for 1-24 hours at the temperature of 30-100 DEG C under mechanical stirring; and cooling to room temperature, filtering, washing the filter cake with hydrochloric acid, dropwise adding hydrochloric acid into the filtrate until the pH value of the filtrate is 2-3, standing, crystallizing, and filtering to obtain 3-trifluoromethyl-4-nitro-phenol solid.
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Paragraph 0020; 0030-0063
(2021/11/10)
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- A practical approach for regioselective mono-nitration of phenols under mild conditions
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Cu(NO3)2.3H2O was demonstrated to be an efficient, regioselective and inexpensive nitrating reagent for the synthesis of mono-nitro substituted phenolic compounds. 12 examples of different phenols were examined. Good yields (67-90%) have been achieved. ARKAT-USA, Inc.
- Chen, Ling-Yan,Liu, Tao,Zhou, Xiaokun,Sun, Zhihua
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- Activation and stabilization of aldimines by an ortho-trifluoromethyl substituent in direct vinylogous Mannich-type reactions
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Lewis acid catalyzed direct vinylogous Mannich-type reaction with a weak nucleophile dienol, generated in situ by ring-opening and rearrangement of vinyloxiranes, could be demonstrated in excellent yields under mild conditions using benzylidene(4-methoxy-2-trifluoromethyl)aniline (MTMA) as an electrophile. The o-trifluoromethyl substituent can stabilize imines by a steric effect and activate by an electron-withdrawing effect. It proved to be an easily deprotectable protecting group for direct Mannich-type reactions.
- Lautens, Mark,Tayama, Eiji,Nguyen, Duy
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p. 5131 - 5133
(2007/10/03)
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- Hydroxylation of Nitroarenes with Alkyl Hydroperoxide Anions via Vicarious Nucleophilic Substitution of Hydrogen
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Rhone-Poulenc Polska Ltd., ul. Grzybowska 80/82, 00-844 Warszawa, Poland Garbo- and heterocyclic nitroarenes react with anions of tert-butyl and cumyl hydroperoxides in the presence of strong bases to form substituted o- and p-nitrophenols. The reaction usually proceeds in high yields and is of practical value as a method of synthesis and manufacturing of nitrophenols. Orientation of the hydroxylation can be controlled to a substantial extent by selection of the proper conditions. Basic mechanistic features of this process were clarified.
- Makosza, Mieczyslaw,Sienkiewicz, Krzysztof
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p. 4199 - 4208
(2007/10/03)
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