- SUBSTITUTED BENZENE COMPOUNDS
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The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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Page/Page column 280
(2012/11/06)
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- Compounds and Compositions as Protein Kinase Inhibitors
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The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
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- INHIBITORS OF STEAROYL-COA DESATURASE
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Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.
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- Process for preparing 2,5-dichloro-3-nitrobenzoic acid
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The invention relates to a process of preparing 2,5-dichloro-3-nitrobenzoic acid by reacting 1,4-dimethyl-2,5-dichloro-3-nitrobenzene with aqueous nitric acid.
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- Terephthalic acid derivatives
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The novel compounds of the formula: STR1 wherein R1 and R2 are each either hydrogen or an alkyl group containing from 1 to 4 carbon atoms, and maybe the same or different, are useful intermediates in a novel process for the preparation of herbicidally active compounds such as 2,5-dichloro-3-nitro-benzoic acid, 2,5-dichloro-3-amino-benzoic acid and their functional derivatives.
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- Sulfonylmethylamino-substituted benzoic acids and herbicidal method therewith
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Novel benzoic acid compounds of the formula STR1 in which R is alkyl or substituted alkyl of up to 6 carbon atoms, where the substituents are selected from halogen, or R is aryl which is optionally substituted by halogen and/or by alkyl of up to 4 carbon atoms, R1 is alkyl, alkoxy or alkylmercapto, of in each case up to 4 carbon atoms, or halogen, R2 is hydrogen, R3 is hydrogen or halogen, R4 is hydroxyl, alkoxy of 1 to 6 carbon atoms or an amino group which is optionally substituted by one or two alkyl radicals each of up to 6 carbon atoms, and R5 is halogen or alkyl of up to 4 carbon atoms; are outstandingly effective and selective as herbicides.
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