- SUBSTITUENT EFFECTS IN THIOPHENE COMPOUNDS. I. 1H NMR AND IR STUDIES IN METHYL (SUBSTITUTED 2-THIOPHENECARBOXYLATE)S.
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The **1H NMR spectra and the IR carbonyl stretching frequencies of methyl (3-, 4-, and 5-substituted 2-thiophenecarboxylate)s have been reported. Good linear correlations between the chemical shifts of the ring protons in methyl (4- and 5-substituted 2-thiophenecarboxylate)s and those of the corresponding protons in substituted thiophenes were observed. The coupling constants in methyl (substituted 2-thiophenecarboxylate)s gave good correlations against the corresponding ones in substituted thiophenes. The IR carbonyl stretching frequencies in methyl (5-substituted 2-thiophenecarboxylate)s were correlated reasonably well with the chemical shifts of 5-protons in 2-substituted thiophenes. The coupling constants in methyl 2-thiophenecarboxylate series were found to very linearly with the electronegativities of the substituents.
- Satonaka
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- BORON CONTAINING COMPOUNDS AND THEIR USES
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The present disclosure contemplates a boron-containing compound, a composition containing a pesticidal effective amount of that compound dissolved or dispersed in a carrier medium, and a method of reducing, ameliorating, or controlling an infestation by a pest, particularly a fungus, by administering a contemplated composition to a plant or animal in need.
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Paragraph 0219-0220; 0223-0224
(2021/01/23)
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- Direct Transformation of Arylamines to Aryl Halides via Sodium Nitrite and N-Halosuccinimide
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A one-pot universal approach for transforming arylamines to aryl halides via reaction with sodium nitrite (NaNO2) and N-halosuccinimide (NXS) in DMF at room temperature under metal- and acid-free condition is described. This new protocol that is complementary to the Sandmeyer reaction, is suggested to involve the in situ generation of nitryl halide induce nitrosylation of aryl amine to form the diazo intermediate which is halogenated to furnish the aryl halide.
- Mukhopadhyay, Sushobhan,Batra, Sanjay
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supporting information
p. 14622 - 14626
(2018/09/21)
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- Efficient transposition of the sandmeyer reaction from batch to continuous process
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The transposition of Sandmeyer chlorination from a batch to a safe continuous-flow process was investigated. Our initial approach was to develop a cascade method using flow chemistry which involved the generation of a diazonium salt and its quenching with copper chloride. To achieve this safe continuous process diazotation, a chemometric approach (Simplex method) was used and extrapolated to establish a fully continuous-flow method. The reaction scope was also examined via the synthesis of several (het)aryl chlorides. Validation and scale-up of the process were also performed. A higher productivity was obtained with increased safety.
- D'Attoma, Joseph,Camara, Titi,Brun, Pierre Louis,Robin, Yves,Bostyn, Stéphane,Buron, Frédéric,Routier, Sylvain
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- Tri- and tetracyclic heteroaromatic systems: Synthesis of novel benzo-, benzothieno- and thienofused pyrano[2,3-c]pyrazol-4(1H)-ones
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A straightforward, two-step synthesis of chromeno[2,3-c]pyrazol-4(1H)-ones, thieno[2′,3′:5,6]pyrano[2,3-c]pyrazol-4(1H)-ones, and [1]benzo-thieno[2′,3′:5,6]pyrano[2,3-c]pyrazol-4(1H)-ones, respectively, is presented. Hence, treatment of 1-substituted or 1
- Eller, Gernot A.,Haring, Andreas W.,Datterl, Barbara,Zwettler, Maryam,Holzer, Wolfgang
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- THE BEHAVIOUR OF VICINAL ALKYL AMINOTHIOPHENECARBOXYLATES IN THE SANDMEYER AND SCHIEMANN REACTIONS
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The diazotization of vicinal alkyl aminothiophenecarboxylates has been studied. 3-Amino compounds gave clear diazonium salts which yielded the expected halo derivatives in the Sandmeyer and Schiemann conditions.However, 2-amino compounds yielded self-coupling products.
- Corral, Carlos,Lasso, Ana,Lissavetzky, Jaime,Alvarez-Insua, Alberto Sanchez,Valdeolmillos, Ana M.
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p. 1431 - 1435
(2007/10/02)
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