Hydrative syntheses of amides from alkynes catalyzed by an Au(I) complex containing pyridyl-functionalized NHC ligand
An Au(I)-NHC complex [L1AuBr] (1) with appended pyridyl group on the ligand scaffold is synthesized and its catalytic efficacy for the direct synthesis of the amide from alkyne and sodium azide in acidic water is evaluated. Catalyst 1 readily converts a wide range of internal and terminal alkynes to the corresponding amides with low catalyst loading in TFA/DCE (2 mL, 1:1 v/v) at room temperature in short reaction time (2 h) and without the use of Ag(I) additive. A related catalyst that is devoid of the pyridyl fragment displays significantly lower activity illustrating the role of the promoter ligand for water activation. Mechanistic studies reveal an initial alkyne hydration to ketone followed by the Schmidt reaction to afford the amide.
Singh, Kuldeep,Pal, Nilay Kumar,Guha, Chirajyoti,Bera, Jitendra K.
p. 1 - 8
(2019/02/25)
Determination of Alkyl Anilines and Alkyl Pyridines in Solvent Refined Coal Distillates and Aqueous Extracts by Gas Chromatography/Mass Spectrometry
Derivatization with acetic anhydride in aqueous media coupled with capillary gas chromatography/mass spectrometry was used to distinguish alkyl anilines from alkyl pyridines.By use of this approach aniline, C-1 anilines, and C-2 anilines, as well as lesse
Felice, Lawrence J.
p. 869 - 872
(2007/10/02)
More Articles about upstream products of 88166-77-2