- Copper-catalyzed intramolecular cross dehydrogenative coupling approach to coumestans from 2′-hydroxyl-3-arylcoumarins
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A copper-catalyzed intramolecular cross dehydrogenative C-O coupling reaction of 2′-hydroxyl-3-arylcoumarins was developed. This protocol provided a facile and efficient strategy for the construction of natural coumestans and derivatives in moderate to high yields. This transformation exhibited good functional group compatibility and was amenable to substrates with free phenolic hydroxyl groups.
- Song, Xianheng,Luo, Xiang,Sheng, Jianfei,Li, Jianheng,Zhu, Zefeng,Du, Zhibo,Miao, Hui,Yan, Meng,Li, Mingkang,Zou, Yong
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p. 17391 - 17398
(2019/06/24)
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- Preparation method of 2,4-dihydroxyphenyl acetic acid
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The invention discloses a preparation method of 2,4-dihydroxyphenyl acetic acid, which comprises the following steps: by using m-bromophenol and glyoxalic acid as raw materials, carrying out condensation reaction and acidification to obtain hydroxy o-bromomandelic acid, reducing the hydroxy o-bromomandelic acid to obtain p-hydroxy o-bromophenyl acetic acid, carrying out bromine hydroxylation reaction on the p-hydroxy o-bromophenyl acetic acid in the presence of a catalyst under alkaline conditions, and carrying out acidification to obtain the 2,4-dihydroxyphenyl acetic acid. The method has the advantages of simple and accessible raw materials, simple reaction treatment and higher yield. The obtained intermediate also has important applications.
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Paragraph 0026; 0027;
(2016/11/17)
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- Synthesis of coumestrol and aureol
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A total synthesis of coumestrol (1) and aureol (2) is described. The Perkin condensation of 2-bromo-4-hydroxylphenylacetic acid (6) and o-hydroxybenzaldehydes (7) gave the corresponding 2′-bromo-3-arylcoumarins (9). A copper-catalyzed consecutive hydroxylation and aerobic oxidative coupling of 9 under microwave conditions facilitated the total synthesis of 1 and 2, respectively, with spectroscopic data highly similar to those of natural products.
- Sheng, Jianfei,Xu, Tianlong,Zhang, Ensheng,Zhang, Xuejing,Wei, Wentao,Zou, Yong
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p. 2749 - 2753
(2016/11/09)
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- BICYCLIC COMPOUND
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The present invention provides a compound having an ACC inhibitory action, which is useful as an agent for the prophylaxis or treatment of obesity, diabetes and the like, and having superior efficacy. The present invention relates to a compound represente
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Page/Page column 246
(2012/06/16)
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