- α-Bromoacrylic Acids as C1 Insertion Units for Palladium-Catalyzed Decarboxylative Synthesis of Diverse Dibenzofulvenes
-
Herein α-bromoacrylic acids have been employed as C1 insertion units to achieve the palladium-catalyzed [4 + 1] annulation of 2-iodobiphenyls, which provides an efficient platform for the construction of diverse dibenzofulvenes. This protocol enables the formation of double C(aryl)-C(vinyl) bonds via a C(vinyl)-Br bond cleavage and decarboxylation. It is particularly noteworthy that the method features a broad substrate scope, and various interesting frameworks, such as bridged ring, fused (hetero)aromatic ring, and divinylbenzene, can be successfully incorporated into the products.
- Zhang, Minghao,Deng, Wenbo,Sun, Mingjie,Zhou, Liwei,Deng, Guobo,Liang, Yun,Yang, Yuan
-
supporting information
p. 5744 - 5749
(2021/08/18)
-
- Indium powder as the reducing agent in the synthesis of 2-amino-1,1′-biphenyls
-
An improved and simplified In-based protocol for the reduction of 2-nitro-1,1′-biphenyls to the corresponding 2-amino-1,1′-biphenyls is disclosed. The method utilizes only a stoichiometric quantity of indium powder as the reducing reagent along with a stoichiometric quantity of ammonium chloride. The work-up is very simple, it requires only a simple filtration of the post-reaction mixture whereupon the reaction medium is removed under reduced pressure. The method was also proven to operate with a variety of functional groups to provide high to excellent yields of the target 2-amino-1,1′-biphenyls. A proposal for a reaction mechanism is also provided.
- Elumalai, Vijayaragavan,Bj?rsvik, Hans-René
-
p. 1224 - 1226
(2016/03/01)
-