Pd-Catalysed direct C(sp2)-H fluorination of aromatic ketones: Concise access to anacetrapib
The Pd-cataylsed direct ortho-C(sp2)-H fluorination of aromatic ketones has been developed for the first time. The reaction features good regioselectivity and simple operations, constituting an alternative shortcut to access fluorinated ketones. A concise synthesis of anacetrapib has also been achieved by using late-stage C-H fluorination as a key step.
IMPROVED MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR
Compounds, compositions, and methods for modulation of Hec1/Nek2 interaction are provided. Such compounds disrupt Nek2/Hec1 binding and may be useful as chemotherapeutic agents for neoplastic diseases
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Paragraph 00316
(2013/06/27)
Modulators Of HEC1 Activity And Methods Therefor
Compounds, compositions, and methods for modulation of Hec1/Nek2 interaction are provided. Especially preferred compounds disrupt Nek2/Hec1 binding and are therefore useful as chemotherapeutic agent for neoplastic diseases.
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Page/Page column 21
(2011/10/10)
Synthesis of aryl ketones by palladium(II)-catalyzed decarboxylative addition of benzoic acids to nitriles
An efficient, sustainable method for the preparation of aryl ketones from ortho-substituted benzoic acids proceeds through their decarboxylation to generate an aryl-palladium species, followed by addition to a nitrile and hydrolysis of the intermediate ketimine.
Lindh, Jonas,Sjoeberg, Per J. R.,Larhed, Mats
supporting information; experimental part
p. 7733 - 7737
(2011/01/05)
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