Practical preparation of Z-α-(N-acetylamino)- and Z-α-(N-benzoylamino)-α,β-unsaturated acids
An efficient two-step synthetic procedure for the preparation of numerous variations of N-protected α,β-unsaturated α-amino acids and their corresponding esters from N-protected glycine and either aliphatic or aromatic aldehydes was developed. The reaction involved cyclization of the N-protected glycine into oxazolone, condensation with the aldehyde, and ring opening with a base. Copyright Taylor & Francis Group, LLC.
Jursic, Branko S.,Sagiraju, Sarada,Ancalade, Dustin K.,Clark, Traneil,Stevens, Edwin D.
p. 1709 - 1714
(2008/02/01)
SYNTHESIS OF DEHYDROPHENYLALANINE DERIVATIVES BY PALLADIUM CATALYZED ARYLATION OF 2-ACETAMIDOACRYLIC ACID
Arylation of 2-acetamidoacrylic acid using Pd(OAc)2/PPh3 or PdCl2(PPh3)2 as catalytic systems leads to α-acetamidocinnamic acids of Z configuration.
Cutolo, M.,Fiandanese, V.,Naso, F.,Sciacovelli, O.
p. 4603 - 4606
(2007/10/02)
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