- Transformations of sym-octahydroxanthene-1,8-diones and 1,8-dioxo-sym-octahydroxanthylium salts in recyclization under the influence of amines
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The chemical behavior of 9-R-sym-octahydroxanthene-1,8-diones and salts based on them in recyclization reactions under the influence of amines was studied. The effect of the basicity of the amines on the direction of recyclization was established. A metho
- Shchekotikhin,Nikolaeva
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Read Online
- Cu catalyzed cross-dehydrogenative coupling reaction for the synthesis of 3-hydroxy-2-pyrrolidinones
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A new convenient strategy for the synthesis of 3-hydroxy-2-pyrrolidinone derivatives featuring regioselective C–C coupling has been developed. This is a Cu (II) catalyzed cross dehydrogenative coupling (CDC) involving enamino-ketones of benzyl amines and di-alkyl acetylenedicarboxylate, followed by cyclization by primary amines. TBHP (tert-butyl hydroperoxide) has been used as the oxidant to promote the coupling protocol. This synthetic route principally demonstrates the scope of CDC reaction and also applicable to gram-scale synthesis.
- Sarkar, Rajib,Mukhopadhyay, Chhanda
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supporting information
p. 3069 - 3076
(2018/07/06)
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- β-Enaminones over recyclable nano-CoFe2O4: a highly efficient solvent-free green protocol
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Abstract: β-Enaminone and its derivatives have emerged among the finest bioactive intermediates. High yields of several β-enaminones (86–97%) are achieved through treatment of substituted aromatic and aliphatic amines with cyclic/acyclic 1,3-diketones, over the magnetically separable cobalt ferrite nanoparticles (CoFe2O4 NPs). The latter was prepared upon co-precipitation. Its purity, fine crystallinity, elemental distributions, morphology, magnetic features, and thermal stability were confirmed by Fourier transform infrared, X-ray diffraction, energy dispersive X-ray spectrometry, scanning electron microscopy, vibrating sample magnetometry, and thermal gravimetric analysis analyses. Thus, CoFe2O4 NPs acted as an excellent green heterogeneous nanocatalyst for synthesis of β-enaminones and gave good recyclability, while showing insignificant loss of their activity. Graphical Abstract: [Figure not available: see fulltext.].
- Eidi, Esmaiel,Kassaee, Mohamad Z.,Cummings, Peter T.
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p. 5787 - 5799
(2018/05/14)
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- Continuous flow iodination using an automated computer-vision controlled liquid-liquid extraction system
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A dynamic computer-vision control system incorporating open-source software technologies (Python, OpenCV) was used to automate a gravity based in-line liquid-liquid extraction during the iodination of enaminones in continuous flow. The system was able to cope with significant colouration of the organic reaction stream and with significant volume/flow changes in the aqueous and organic phase streams due to extraction of the water soluble acetonitrile co-solvent.
- O'Brien, Matthew,Cooper, Dennis A.,Dolan, Jonathan
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p. 829 - 834
(2017/02/10)
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- Library design, synthesis and biological exploration of novel 3,4′-bicarbostyril derivatives as potent antimicrobial, antitubercular and antimalarial agents
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Abstract: A library comprises diversely substituted novel 3,4′-bicarbostyril derivatives have been designed by molecular hybridization technique and synthesized via multi-component reaction. Compounds G22 (MIC = 12.5 μg/mL) and G38 (MIC = 25 μg/mL) exhibited 99% inhibition against Mycobacterium tuberculosis, while compounds G40 (IC50 = 0.019 μg/mL) and G20 (IC50 = 0.028 μg/mL) found to have excellent activity against Plasmodium falciparum. Compounds G37 (MIC = 25 μg/mL) and G8, G18, and G38 (MIC = 50 μg/mL) elicited excellent antimicrobial activity compared to standard drugs. Biological results revealed that the potency of the title compounds strongly depends on the length and flexibility of various spacers at N?1, the electronic influence of substituent at R1 and lipophilicity of CH3 group at R2 position on bicarbostyril system. Graphical Abstract: [InlineMediaObject not available: see fulltext.]
- Jardosh, Hardik H.,Vala, Nileshkumar D.,Patel, Manish P.
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p. 881 - 899
(2017/04/13)
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- Nano-SiO2 catalyzed synthesis of β-enaminones under solvent free conditions
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Nano-SiO2 efficiently catalyzed the synthesis of β-enaminones using direct condensation of various (cyclic and acyclic) β-diketones with aromatic and aliphatic amines under solvent-free conditions. This eco-friendly catalyst can be recovered and reused without significant loss of activity. This methodology provides a simple synthetic route to enaminones in excellent yields at room temperature. Graphical abstract: [Figure not available: see fulltext.]
- Alinezhad, Heshmatollah,Tajbakhsh, Mahmood,Sarkati, Malihe Norouzi,Zare, Mahboobe
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p. 1591 - 1596
(2016/08/16)
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- Continuous Flow Liquid-Liquid Separation Using a Computer-Vision Control System: The Bromination of Enaminones with N -Bromosuccinimide
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Incorporating open-source software components (Python, OpenCV), a computer-vision system was used to control the interface level in a gravity-based inline liquid-liquid separation device. This was used in the continuous flow bromination of a series of enaminone substrates. The main byproduct of the reaction, succinimide, was efficiently extracted into the aqueous stream, providing clean products without the need for further purification.
- O'Brien, Matthew,Cooper, Dennis
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supporting information
p. 164 - 168
(2015/12/26)
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- 3-AMINO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES
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Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
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Page/Page column 203; 204
(2016/05/09)
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- Synthesis, spectral and structural characterization of cobalt(III) dithiocarbamato complexes: Catalytic application for the solvent free enamination reaction
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The syntheses, spectral, structural and catalytic properties of some new cobalt(III) complexes, [Co(mpcdt)3] (1), [Co(ppcdt)3] (2) and [Co(mppcdt)3]·0.25CHCl3 (3), derived from 4-methyl piperazine-1-carbodithioate (mpcdt), 4-phenyl piperazine-1-carbodithioate (ppcdt) and 4-(2-methoxyphenyl) piperazine-1-carbodithioate (mppcdt) have been described. A series of β-enaminoesters and β-enaminones were obtained in about 90% yield by the reactions of β-ketoesters and 1,3-diketones with aliphatic and aromatic amines using 1-2 mol% of the above cobalt(III) complexes as catalysts and these have been characterized by NMR, GC-MS and X-ray crystallography. Complexes 1, 2 and 3 are stabilized by intermolecular C-H?S interactions, leading to the formation of supramolecular architectures. Thermogravimetric analysis of complexes 1 and 2 have been investigated by TG-DTA, which indicate that cobalt sulfide is formed as the final product.
- Bharati, Pooja,Bharti,Nath,Bharty,Butcher,Singh
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p. 375 - 385
(2015/11/03)
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- Regioselective one-pot synthesis of functionalised 6,7-dihydro-1H-indol-4(5H )-ones
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A one-pot two-step synthesis of functionalised 6,7-dihydro-1H-indol-4(5H )-ones from 1,3-cyclohexanediones, benzylamines, and 2-(2-oxo-2-phenylethylidene)-1H-indene-1,3(2H )-dione has been achieved. The advantages of this approach are operational simplicity, good yields of the products and avoidance of the use of any ligands, metal catalysts, acidic media, or column chromatography.
- Alizadeh, Abdolali,Bayat, Fahimeh
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p. 166 - 169
(2015/06/02)
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- FeCl3-Catalyzed Combinatorial Synthesis of Functionalized Spiro[Indolo-3,10′-indeno [1,2- b ]quinolin]-trione Derivatives
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An efficient, inexpensive, environmentally friendly and high yield one-pot route to new spiro[indolo-3,10′-indeno [1,2-b]quinolin]-trione derivatives has been developed, involving three-component reaction of enaminones, N-substituted isatins and Indane-1,3-dione catalyzed by FeCl3. The approach to this spiro-heterocycle is noteworthy because it results in the formation of three new σ (two C-C and one C-N) bonds in a single operation, leading to the construction of novel spiro skeleton. This method works on a large scale in excellent yields.
- Mondal, Animesh,Mukhopadhyay, Chhanda
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supporting information
p. 404 - 408
(2016/01/15)
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- Diels-Alder construction of regiodifferentiated meta-amino phenols and derivatives
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Synthetic access to regiodifferentiated meta-amino phenols is described. The strategy relies upon distinct deprotonation conditions to afford regioisomeric thermodynamic and kinetic dienes that undergo a tandem Diels-Alder and retro-Diels-Alder sequence with assorted acetylenic dienophiles to afford a range of aromatic products.
- Weaver, Marisa G.,Bai, Wen-Ju,Jackson, Stephen K.,Pettus, Thomas R. R.
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supporting information
p. 1294 - 1297
(2014/04/03)
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- Vanadium(IV) acetylacetonate catalyzed stereoselective synthesis of β-enaminoesters and β-enaminones
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An efficient and stereoselective procedure has been described for the synthesis of a series of β-enaminoesters and β-enaminones by vanadium(IV) acetylacetonate [VO(acac)2] catalyzed reaction of β-ketoesters and 1,3-diketones with both aliphatic and aromatic amines. X-ray crystallographic studies of some representative compounds corroborate two types of structural geometry formed by inter-molecular as well as intra-molecular hydrogen bonds.
- Laskar, Rajibul A.,Begum, Naznin A.,Hedayetullah Mir, Mohammad,Ali, Shahzad,Khan, Abu T.
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p. 436 - 440
(2013/02/23)
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- Phosphomolybdic acid (PMA) catalyzed highly efficient and rapid synthesis of ss-enaminones
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ss-Enamino derivatives have been synthesized by the condensation of amines and ss-dicarbonyl compounds in the presence of 1 mol% of phosphomolybdic acid (PMA) at room temperature in good to excellent yields. Taylor & Francis Group, LLC.
- Nagaiah,Purnima,Sreenu D.,Jhansi S.,Rao, R. Srinivasa,Yadav
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experimental part
p. 461 - 468
(2011/12/04)
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- Efficient synthesis of tetrahydroquinolinones by acetic acid-mediated formal [3+3] cycloaddition
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A simple and efficient method to synthesize a variety of tetrahydroquinolinones was successfully achieved by reacting various β-enaminones with several α,β-unsaturated aldehydes. This strategy can be viewed as a Bronsted acid-mediated formal [3+3] cycloaddition. Springer-Verlag 2012.
- To, Quang Huy,Lee, Yong Rok,Kim, Sung Hong
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p. 1421 - 1426
(2012/11/07)
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- Efficient one-pot synthesis of acridinediones by indium(III) triflate-catalyzed reactions of β-enaminones, aldehydes, and cyclic 1,3-dicarbonyls
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An efficient one-pot synthesis of acridinediones by In(OTf) 3-catalyzed reactions was developed starting from β-enaminones, aldehydes, and cyclic 1,3-diketones. The key strategies of these reactions involve domino Knoevenagel condensation/Michael addition/cyclodehydration reaction.
- To, Quang Huy,Lee, Yong Rok,Kim, Sung Hong
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body text
p. 1170 - 1176
(2012/07/14)
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- Silica sulfuric acid-mediated synthesis of β-enaminones and β-enaminoesters under microwave irradiation
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Silica sulfuric acid, a heterogeneous reagent, has been found to be an efficient catalyst for the synthesis of β-enaminones and β-enaminoesters under microwave irradiation in a microwave reactor within 2 min. The experimental procedure is simple and environment-friendly, and results in excellent yields of the products. Further, the catalyst is recyclable, and the reaction is 60 times faster than the reaction at room temperature. Copyright Taylor & Francis Group, LLC.
- Datta, Bandita,Pasha
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experimental part
p. 171 - 177
(2011/04/22)
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- Molecular iodine-catalyzed mild and effective synthesis of β-enaminones at room temperature
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Molecular iodine has been found to be an efficient and ecofriendly catalyst for the synthesis of β-enaminones from dimedone and amines at room temperature in the presence of acetonitrile within 60 min. The experimental procedure is simple, includes shorter reaction times, and results in excellent yields of the products. Copyright
- Datta, Bandita,Reddy, M. B. Madhusudana,Pasha
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experimental part
p. 2331 - 2336
(2011/06/27)
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- Zeolite (ZSM-5) as a highly efficient and heterogeneous catalyst for the synthesis of β-Enaminones and β-Enamino esters
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Several β-enaminones and β-enaminoesters have been synthesized in high yields from amine and β-diketone in the presence of Zeolite (ZSM-5) as a catalyst. This method is applicable to both cyclic and acyclic ketones with aromatic and aliphatic amines. Copyright E-Journal of Chemistry 2004-2011.
- Shekhar, Amiya,Pathak, Devendra Deo
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experimental part
p. 1632 - 1637
(2012/05/07)
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- Silica-supported LiHSO4 as a highly efficient, heterogeneous and reusable catalytic system for the solvent-free synthesis of β-enaminones and β-enamino esters
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A highly efficient, simple and green procedure for the synthesis of β-enaminones and β-enamino esters is described. The reaction of aromatic and aliphatic amines with β-dicarbonyl compounds using catalytic amount of silica-supported LiHSO4 (LiHSO4/SiO2) under solvent-free conditions at 80 °C affords the title compounds in high to excellent yields and in short reaction times.
- Hasaninejad,Zare,Mohammadizadeh,Shekouhy
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experimental part
p. 69 - 76
(2010/10/21)
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- A green solventless protocol for the synthesis of β-Enaminones and β -Enamino esters using silica sulfuric acid as a highly efficient, heterogeneous and reusable catalyst
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Silica sulfuric acid is utilized as a green, highly efficient, heterogeneous and recyclable catalyst for the preparation of β-enaminones and β -enamino esters from amines and β -dicarbonyl compounds under solvent-free conditions at 80 °C. Using this method, the title compounds are produced in high to excellent yields and in short reaction times.
- Hasaninejad, Alireza,Zare, Abdolkarim,Mohammadizadeh, Mohammad Reza,Shekouhy, Mohsen,Moosavi-Zare, Ahmad Reza
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experimental part
p. 1546 - 1554
(2011/12/05)
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- P2O5/SiO2 as a new, efficient, and reusable catalyst for preparation of β-enaminones under solvent-free conditions
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P2O5/SiO2 (30% w/w) was applied as an efficient, heterogeneous, and reusable catalyst for the synthesis of β-enaminones. The reactions were rapidly completed at 80°C under solvent-free conditions and products were obtained in good to excellent yields. Copyright Taylor & Francis Group, LLC.
- Mohammadizadeh, Mohammad R.,Hasaninejad,Bahramzadeh,Khanjarlou, Z. Sardari
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experimental part
p. 1152 - 1165
(2009/10/09)
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- Partially saturated indeno[1,2-b]indole derivatives via deoxygenation of heterocyclic α-hydroxy-N,O-hemiaminals
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A series of 3-aminocyclohex-2-enones were reacted with indane-1,2,3-trione monohydrate (ninhydrin) yielding 4b,9b-dihydroxyindeno[ 1,2-b]indoles that were deoxygenated to indeno[1,2-b]indoles. Georg Thieme Verlag Stuttgart.
- Hemmerling, Hans-Joerg,Reiss, Guido
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experimental part
p. 985 - 999
(2009/12/01)
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- Ceric(IV) ammonium nitrate catalyzed synthesis of β-enaminones
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β-Enaminones have been synthesized in good yield from 1,3-dicarbonyl compounds and activated amines in the presence of ceric ammonium nitrate as catalyst.
- Paira,Misra,Roy
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p. 966 - 969
(2008/12/23)
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- Uncatalyzed synthesis of β-enamino ketones in PEGWater
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β-Enamino ketones have been synthesized in excellent yield by the reaction of aromatic or aliphatic amines with 1,3-dicarbonyl compounds in polyethylene glycol (PEG)-600water. The PEG-600 is recycled and reused. CSIRO 2008.
- Bandgar, Babasaheb P.,Patil, Sachin A.,Korbad, Balaji L.,Bandgar, Sunita B.,Hote, Baliram S.
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p. 552 - 555
(2008/12/20)
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- Anticonvulsant evaluation and mechanism of action of benzylamino enaminones
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The mechanism of anticonvulsant action was evaluated for the benzylamino enaminones. The most potent enaminone in this series was the unsubstituted benzylamine analog (30; methyl 4-benzylamino-6-methyl-2-oxocyclohex-3-en-1-oate) which had an oral effective dose (ED50) in rats of 27 mg/kg against maximal electroshock seizures, and a concentration 10-fold less than this dose depressed excitatory synaptic transmission, and action potential firing in the rat brain in vitro.
- Edafiogho, Ivan O.,Ananthalakshmi, Kethireddy V.V.,Kombian, Samuel B.
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p. 5266 - 5272
(2007/10/03)
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- Ionic liquid promoted synthesis of β-enamino ketones at room temperature
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β-Enamino ketones have been synthesised in excellent yield at room temperature in the absence of any added catalyst by the reaction of aromatic or aliphatic amines with 1,3-dicarbonyl compounds in ionic liquid. The ionic liquid is recycled and reused several times. Georg Thieme Verlag Stuttgart.
- Bhosale, Rajesh S.,Suryawanshi, Padmakar A.,Ingle, Sachin A.,Lokhande, Mahendra N.,More, Sandeep P.,Mane, Sandeep B.,Bhosale, Sidthanath V.,Pawar, Rajendra P.
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p. 933 - 935
(2007/10/03)
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- Ionic liquid promoted simple and efficient synthesis of β-enamino esters and β-enaminones from 1,3-dicarbonyl compounds - One-pot, three-component reaction for the synthesis of substituted pyridines
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A facile enamination of 1,3-dicarbonyl compounds with amines has been developed that affords good to excellent yields of β-enamino esters and β-enaminones using Bronsted acidic ionic liquid 1-methylimidazolium trifluoroacetate ([Hmim]+Tfa-) at room temperature. This methodology has been extended for the synthesis of substituted pyridines in excellent yield by a one-pot, three-component reaction of 1,3-dicarbonyl compounds, ammonium acetate, and alkynone in the presence of [Hmim] +Tfa-.
- Karthikeyan, Ganesan,Perumal, Paramasivan T.
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p. 1746 - 1751
(2007/10/03)
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- An efficient microwave assisted solvent-free general route to cyclic enaminones
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1,3-Cyclohexanedione and dimedone have been reacted with primary amines in domestic microwave oven to give cyclic enaminones 2a-h in very good to excellent yields.
- Chanda, Kaushik,Dutta, Milan Chandra,Vishwakarma
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p. 2475 - 2477
(2007/10/03)
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- Rigid core vinamidinium salts and their N,N′-rotamers
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The power of proton magnetic resonance spectroscopy to unravel stereochemical details is amply demonstrated. O-Methylation of 3-methylamino-5,5-dimethyl-2-cylohexen-1-one (1a) produces stable diastereomers, (Z)- and (E)-N-(3-methoxy-5,5-dimethyl-2-cyclohexen-1-ylidine)-N-methylaminium iodide (2a). As predicted by computation and confirmed by spectroscopy, the (Z)-vinylogous imidate salt predominates. Reaction of 2a with primary and secondary amines furnished a number of vinamidinium salts, including N-(3-methylamino-5,5-dimethyl-2-cyclohexen-1-ylidene)-N-methylaminium iodide (3a). Two rotamers of 3a were identified and characterized. A substantial number of additional compounds 2 and 3 are included in the study.
- Ostercamp, Daryl L.,Dinh, Yen,Graff, David,Wiles, Sarah
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p. 3099 - 3105
(2007/10/03)
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- Peculiarities of formation of decahydroacridine-1,8-diones on the basis of 1,3-dioxocyclohexane compounds in various media
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The conditions for the formation of N-substituted decahydroacridine-1,8-diones from α-R-methylenebiscyclohexane-1,3-diones and 5,5-dimethyl-3-(N-methylamino)-2-cyclohexen-1-one in ethanol, isopropanol, and DMSO have been studied. Methods have been develop
- Nikolaeva,Shchekotikhin,Ponomarev,Kriven'ko
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p. 403 - 409
(2007/10/03)
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- Photorearrangement of N-alkanoyl β-enaminones. Application to the synthesis of α-amino-β,γ-unsaturated acid derivatives
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The irradiation of N-alkanoyll-β-enaminones lead to the formation of spiranic β-lactams which undergo C-N bond cleavage during chromatography on alumina giving cycloalkenones functionalized at position 3. This new rearrangement has been applied to the synthesis of α-amino-β,γ-unsaturated amides in one step and gives convenient yields.
- Amougay,Letsch,Pete,Piva
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p. 2405 - 2420
(2007/10/03)
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- Intramolecular [2 + 2] photocvcloaddition of N-alkenovl-β-enaminones
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The photolysis of cyclic N-alkenoyl β-enaminones is described. In general, a very regio- and stereoselective intramolecular [2 + 2] photocydoaddition was observed. The limitations of the reaction process are discussed. The main competitive reaction, which
- Amougay, Aicha,Pete, Jean-Pierre,Piva, Olivier
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p. 625 - 635
(2007/10/03)
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- Synthesis and Anticonvulsant Activity of Enaminone. 2. Further Structure-Activity Correlations.
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This report continues the in-depth evaluation of methyl 4--6-methyl-2-oxocyclohex-3-en-1-oate, 1 (ADD 196022), and methyl 4-(benzylamino)-6-methyl-2-oxocyclohex-3-en-1-oate, 2, two potent anticonvulsant enaminones.These compounds were evaluated employing the amygdala kindling model.Neither 1 nor 2 was active against amygdala kindled seizures, further supporting the corneal kindled model as a definitive tool for antielectroshock seizure evaluation as previously reported.Additional intraperitoneal (ip) data on 1 revealed toxicity at 24 h at 100 mg/kg.Several active analogs have been prepared with the view to minimizing toxicity.In a special ip rat screen developed by the Antiepileptic Drug Development (ADD) Program, these newer analogs were evaluated for protection against maximal electroshock seizures (MES) at 10 mg/kg and neurotoxicity at 100 mg/kg.From this screen, several compounds were shown to be safer alternatives, the most notable was methyl 4--6-methyl-2-oxocyclohex-3-en-1-oate, 13.Compound 13 had an ip ED50 of 4 mg/kg in the rat and a TD50 of 269 mg/kg, providing a protective index (TD50/ED50) of > 67.By variation in the ring size, additional aromatic substitutions and the synthesis of acyclic analogs, these newer compounds provide a more definitive insight into the structure-activity correlation.CLOGP evaluation and molecular modeling studies are also provided to further elaborate the molecular characteristics of potential anticonvulsant enaminones.
- Scott, K. R.,Edafiogho, Ivan O.,Richardson, Erica L.,Farrar, Vida A.,Moore, Jacqueline A.,et al.
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p. 1947 - 1955
(2007/10/02)
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- Synthesis and anticonvulsant activity of enaminones
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A new series of novel enaminones has been synthesized from cyclic β- dicarbonyl precursors which were condensed with morpholine, pyrrolidine, phenethylamine, hydrazines, substituted benzyl amines, and substituted anilines. These compounds were subsequentl
- Edafiogho,Hinko,Chang,Moore,Mulzac,Nicholson,Scott
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p. 2798 - 2805
(2007/10/02)
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- Regioselective Synthesis of the Kinamycin ABCD ring system
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The new bromoquinone-enamine annulation was successfully extended to acyclic enamino ketones resulting in a new synthesis of the ABC framework 7 of kinamycins and when applied to cyclic enamino ketones 8a-c the first synthesis of their ABCD ring system.Smooth aromatisation of compounds 4b,d to 9a,b respectively was effected with DDQ. - Key Words: regiospecific annulation, metal catalysed; kinamycin; tetrahydrobenzocarbazole
- O'Sullivan, Patrick J.,Moreno, Rafael,Murphy, William S.
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p. 535 - 538
(2007/10/02)
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- Base-promoted Reactions of β-Enaminones with 2-Bromo-2-methylpropanamides. Formation of 2-Ketonyloxazolidin-4-ones and Cyclohexanespiro-oxazolidin-4-ones
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Representative β-enaminones (1) and (2) react with N-alkyl-2-bromo-2-methylpropanamides (4a), (4b), and (4c) in the presence of NaH, to afford oxazolidin-4-ones (5) and (6) or spiro-oxazolidinone derivatives (7) and (8).The formation of an imidazolidin-4-one derivative (9) from 2-bromo-2-methylpropanilide (4c) is ascribed to the presence of an intermediate α-lactam (15).The behaviour of a spiro-oxazolidinone derivative on hydrolysis, reduction, and thiation is described.
- Veronese, Augusto C.,Scrimin, Paolo,Vecchiati, Giorgio,Sferra, Stella,D'Angeli, Ferruccio
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p. 781 - 784
(2007/10/02)
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- N-ALKYLATION OF ENAMINONES
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The base catalyzed N-alkylation of a series of primary and secondary enaminones has been examined in detail.The enaminone anion was found to be a weak nucleophile.Best results were obtained in tetrahydrofuran or dioxane with sodium hydride and an alkyl io
- Greenhill, John V.,Moten, Ashraf M.
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p. 3405 - 3408
(2007/10/02)
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- Participation of Vinylogous Carbonamide Groups Through the Generation of Carbiminium Compounds
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Mercury EDTA dehydrogenation with Mannich bases derived from enaminones of dimedone and having a cyclic amine part mostly shows a neighbouring participation.From aromatically substituted vinylogous amides lactamamides are produced, while aliphatic substit
- Moehrle, H.,Herbke, J.
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p. 389 - 393
(2007/10/02)
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