Establishing the NHBoc functionality as ortho-metallating group for furan
The ortho-lithiation of N-Boc protected 3-aminofuran was investigated. Directed lithiation followed by quenching with an appropriate electrophile led to new 2,3-disubstituted furans. Halogenated compounds obtained by this methodology represent useful inte
Stanetty, Peter,Kolodziejczyk, Krzystztof,Roiban, Gheorghe-Doru,Mihovilovic, Marko D.
HYDROXYQUINOLIN-2(1H)-ONES AND DERIVATIVES THEREOF
This invention relates to known and novel hydroxyquinolin-2(1H)-ones and derivatives thereof which are useful for the treatment of cognitive-related disorders and neuropathic pain disorders in a mammal, e.g., a human. The invention also relates to pharmaceutical compositions containing such compounds.
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Page/Page column 56
(2010/07/10)
Synthesis of potential fungicides based on N-(3-furanyl)pyrrolecarboxamides and N-(3-furanyl)pyrazolecarboxamides
An efficient synthesis of novel N-(3-furanyl)pyrrolecarboxamides and N-(3-furanyl)pyrazolecarboxamides is presented starting from furan-3-carboxylic acid. Two complementary strategies to 2-aryl-3-furanamines with directed ortho lithiation, functionalizati
Kolodziejczyk, Krzysztof,Roiban, Gheorghe D.,Schnuerch, Michael,Mihovilovic, Marko D.,Stanetty, Peter
experimental part
p. 1349 - 1359
(2010/05/18)
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