- Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles
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We report here the transformation of 3/5-trifluoromethylpyrazoles derivative into the corresponding NH-pyrazole-3/5-carboxylic acids. Moreover, from 4- or 5-iodinated-3/5-trifluoromethylpyrazoles building blocks and the use of Suzuki-Miyaura or Negishi reactions followed by the trifluoromethyl hydrolysis, we illustrate short and original accesses to many series of NH-pyrazole-3/5-carboxylic acids otherwise difficult to prepare.
- Ermolenko, Mikhail S.,Guillou, Sandrine,Janin, Yves L.
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p. 257 - 263
(2013/01/15)
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- Metal and boron derivatives of fluorinated cyclic 1,3-dicarbonyl compounds
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Starting from the corresponding cyclic 1,3-diketones or other precursors (cyclic ketones as well as lactones), several new salts and chelate complexes of fluorinated 1,3-dicarbonyls were obtained. Their preparative significance was demonstrated by straigh
- Sevenard, Dmitri V.,Khomutov, Oleg G.,Boltachova, Nadezhda S.,Filyakova, Vera I.,Vogel, Vera,Lork, Enno,Vyacheslav Ya. Sosnovskikh,Iaroshenko, Viktor O.,Roeschenthalerc, Gerd-Volker
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experimental part
p. 541 - 550
(2009/09/07)
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- HETEROCYCLES USEFUL AS INHIBITORS OF CARBONIC ANHYDRASE
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Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.
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Page/Page column 82-83
(2008/06/13)
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- The structure of fluorinated indazoles: The effect of the replacement of a H by a F atom on the supramolecular structure of NH-indazoles
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The structures of three NH-indazoles (3-methyl, 3-trifluoromethyl and 3-trifluoromethyl-4,5,6,7-tetrafluoroindazoles) have been determined by X-ray crystallography. These three compounds, together with 3-methyl-4,5,6,7- tetrafluoroindazole, whose X-ray st
- Teichert, Johannes,Oulie, Pascal,Jacob, Kane,Vendier, Laure,Etienne, Michel,Claramunt, Rosa M.,Lopez, Concepcion,Perez Medina, Carlos,Alkorta, Ibon,Elguero, Jose
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p. 936 - 946
(2008/02/12)
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- Novel polyfluoroalkylated pyrazoles from 2-polyfluoroacylcycloalkanones and hydrazines: Syntheses and unequivocal molecular structure assignment
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The reaction between 2-trifluoroacetylcycloalkanones and methylhydrazine or phenylhydrazine exclusively yields 3-CF3-pyrazoles. When the chain length of the polyfluorinated substituent in RFC(O) group increases, 5-RF-pyraz
- Sevenard,Khomutov,Kodess,Pashkevich,Loop,Lork,Roeschenthaler
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p. 183 - 194
(2007/10/03)
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- Convenient and versatile synthesis of 3-(polyfluoroalkyl)pyrazoles
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3-(Polyfluoroalkyl)pyrazoles 4 have been synthesized in excellent yields in a two-step sequence from polyfluoroalkyl iodides 1.The synthesis consisted of the reaction of iodides 1 with enamines or enol ethers to give α-polyfluoroalkyl carbonyl derivatives 3 followed by treatment with hydrazine monohydrate.A practical one-pot synthesis of pyrazoles 4 from iodides 1 gas also been developed and the reaction mechanism is discussed.
- Tang, Xiao-Qing,Hu, Chang-Ming
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p. 1039 - 1044
(2007/10/02)
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