Regioselective synthesis of 3-aryl-5-(1H-indole-3-carbonyl)-4-hydroxyfuroic acids as potential insulin receptor activators
3-Methoxy-4-aryl-furan-2,5-dicarboxylic acid (8) is selectively converted into its C-5 methylester (6) by treatment with methyl chloroformate followed by decarboxylation in one flask. Acylation of the resulting half ester with a 7-substituted indole was p
This invention relates to treating diabetes mellitus with certain 4-hydroxyfuroic acid derivatives. These derivates are of formula (I) below. Each variable is defined in the specification.
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(2010/11/08)
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