Synthesis and Inhibition of Human Acrosin and Trypsin and Acute Toxicity of Aryl 4-Guanidinobenzoates
The aryl 4-guanidinobenzoate, 4'-nitrophenyl 4-guanidinobenzoate (NPGB), is potent inhibitor of sperm acrosin, an enzyme with an essential function in the fertilization process.NPGB prevents fertilization in a number of animal species and is a good lead c
Kaminski, J. M.,Bauer, L.,Mack, S. R.,Anderson, R. A.,Waller, D. P.,Zaneveld, L. J. D.
p. 514 - 519
(2007/10/02)
Contraceptive method
Contraceptive method comprises maintaining in the genital tract of a mammal an ester of 4-guanidinobenzoic acid and certain substituted phenols in a concentration effective to inhibit the fertilization of ova. In addition to effectively inhibiting the enz
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(2008/06/13)
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