- A PROCESS FOR THE SYNTHESIS OF ANTHRANILIC ACID/AMIDE COMPOUNDS AND INTERMEDIATES THEREOF
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The present invention disclosed a process for the synthesis of compound of formula (Z) or a salt thereof, wherein, R, R1, R2, R3 and R10 are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).
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- A PROCESS FOR THE SYNTHESIS ANTHRANILIC DIAMIDE COMPOUNDS AND INTERMEDIATES THEREOF
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The present invention disclosed a process for the synthesis of anthranilic diamide compound of formula (I), wherein, R1, R2, R3a, R3b, R3c, R4, R5, R6 and Z are as defined in the detailed description. The process comprising the step of obtaining a mono- or dicyano substituted aniline compound of formula (IV) which is then converted to an anthranilic acid compound of formula (V) or an anthranilic amide compound of formula (Va). Further, the compound of formula (VI) can be optionally synthesized from compound of formula (IV or V or Va).
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- Cyan dihalogenation pyrazol amide series compound and preparation method and application thereof
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The invention discloses a cyan dihalogenation pyrazol amide series compound and a preparation method and application thereof. The general chemical molecular formula of the compound is CHNOClBrR1R2, wherein R1 represents methyl, Cl or Br; R
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Paragraph 0047; 0048; 0049
(2016/10/09)
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- METHOD FOR THE PRODUCTION OF 2-AMINO-5-CYANO-N,3-DIMETHYLBENZAMIDE
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The present invention relates to a process for preparing 2-amino-5-cyano-N,3-dimethylbenzamide of formula (1) by reacting 2-amino-5-cyano-3-methylbenzoic esters or diesters with methylamine.
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Paragraph 0103; 0104; 0110
(2014/06/11)
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- PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES
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Disclosed is a method for preparing a compound of Formula 1 comprising contacting a compound of Formula 2 with a metal cyanide reagent, a copper(I) salt reagent, an iodide salt reagent and at least one compound of Formula 3 wherein R1 is (NHRs
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Page/Page column 31
(2009/08/14)
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- PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES
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Disclosed is a method for preparing a compound of Formula (1) comprising contacting a compound of Formula (2) with a metal cyanide reagent, a copper (I) salt reagent, an iodide salt reagent and at least one compound of Formula (3), wherein R1 i
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Page/Page column 31-32
(2009/10/22)
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- PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES
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Disclosed is a method for preparing a compound of Formula 1 comprising (1) contacting a compound of Formula 2, with (2) at least one alkali metal cyanide and (3) at least one compound of Formula (4); wherein R1 is NHR3 or OR4; R2 is CH3 or Cl; R3 is H, C1-C4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl or methylcyclopropyl; R4 is H or C1-C4 alkyl; and X is Br, Cl or I. Also disclosed is a method for preparing a compound of Formula (4 )comprising contacting a mixture of (i) at least one compound of Formula (9 )and (ii) at least one metal reducing agent with (iii) dichlorobis(triphenylphosphine)nickel, and further disclosed is a method for removing nickel impurities from a mixture thereof with compounds of Formula (1 )comprising contacting the mixture with oxygen in the presence of an aqueous cyanide solution, and additionally disclosed is a method for preparing a compound of Formula (5); wherein R5, R6, R7 and Z are as defined in the disclosure, using a compound of Formula (1,) characterized by preparing the compound of Formula (1) by the method disclosed above.
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Page/Page column 29-30
(2009/03/07)
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- PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES
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Disclosed is a method for preparing a compound of Formula 1 comprising contacting a compound of Formula 2 with at least one alkali metal cyanide of Formula 3 and a compound of Formula 4 wherein R1 is NHR3 or OR4; R2 is CH3 or Cl; R3 is H, C1-C4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl or methylcyclopropyl; R4 is H or C1-C4 alkyl; X is Br, Cl or I; and R5, R6, R7, R8, R9 and R10 are as defined in the disclosure. Also disclosed is a method for preparing a compound of Formula 4 wherein R9 and R10 together are a cycloalkadiene bidentate ligand, comprising contacting a compound of Formula 5 wherein Y is Cl, Br or I, with a cycloalkadiene bidentate ligand, at least one metal reducing agent and a nitrile solvent. Also disclosed is a method for preparing a compound of Formula 1 comprising preparing a compound of Formula 4 by contacting a compound of Formula 5 with a cycloalkadiene bidentate ligand and at least one metal reducing agent, and then contacting the reaction mixture comprising the compound of Formula 4 with a compound of Formula 2 and at least one alkali metal cyanide of Formula 3; and further disclosed is a method for preparing a compound of Formula 6 wherein R15, R16, R17 and Z are as defined in the disclosure using a compound of Formula 1, characterized by preparing the compound of Formula 1 by a method disclosed above.
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Page/Page column 40-41
(2009/06/27)
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- PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES
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Disclosed is a method for preparing a compound of Formula (1) comprising contacting a compound of Formula (2) with at least one compound of Formula 3 in the presence of a solvent comprising one or more organic solvents selected from ethers and nitriles an
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Page/Page column 30
(2008/12/06)
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- PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES
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Disclosed is a method for preparing a compound of Formula (1) comprising contacting a compound of Formula (2) with a metal cyanide reagent, a copper (I) salt reagent, an iodide salt reagent and at least one compound of Formula (3): wherein R1 i
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Page/Page column 30
(2008/12/07)
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- METHOD FOR PREPARING N-PHENYLPYRAZOLE-1-CARBOXAMIDES
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A method is disclosed for preparing compounds of Formula (I) by combining compounds of Formulae (II and III) and a sulfonyl chloride. Also disclosed are compounds of Formula (III), which are useful as starting materials for this method.
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Page/Page column 25
(2008/06/13)
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