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892128-60-8

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Synthesis, crystallization, and biological evaluation of an orally active prodrug of gemcitabine
The design, synthesis, and biological characterization of an orally active prodrug (3) of gemcitabine are described. Additionally, the identification of a novel co-crystal solid form of the compound is presented. Valproate amide 3 is orally bioavailable a
p. 6958 - 6961
(2009)
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ORALLY ACTIVE PRODRUG OF GEMCITABINE
The disclosure includes compounds of Formula (I): wherein R1, R2, and R3, are defined herein. Also disclosed is a method for treating a neoplastic disease with these compounds.
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Page/Page column 23-24

(2020/06/10)

GEMCITABINE ANALOGS
Gemcitabine analogs, including monophosphorylated analogs, are described herein and are suitable for use in pharmaceutical compositions, kits and treatment methods. The treatment methods include treatment of viral infections, including, but not limited to
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(2015/09/28)

CRYSTALLINE FORMS OF GEMCITABINE AMIDE PRODRUG, COMPOSITIONS AND USE THEREOF
The present invention relates to novel crystal forms of an amide prodrug of gemcitabine, compositions thereof and methods for using.
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Page/Page column 6-7

(2008/06/13)

AMIDE PRODRUG OF GEMCITABINE, COMPOSITIONS AND USE THEREOF
The present invention relates to novel amide prodrugs of gemcitabine, compositions thereof and methods for using.
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Page/Page column 5

(2008/06/13)

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Chemical Properties

Density: 1.41±0.1 g/cm3(Predicted)
Solubility:Soluble in DMSO
PKA: 9.66±0.20(Predicted)
PSA: 117.17000
LogP: 1.11830

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