- New catechol derivatives of safrole and their antiproliferative activity towards breast cancer cells
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Catechols were synthesized from safrole. Nine derivatives were prepared and assessed for antiproliferative effects using different human cell lines. The in vitro growth inhibition assay was based on the sulphorhodamine dye to quantify cell viability. The derivatives 4-allylbenzene-1,2-diol (3), 4 4-[3-(acetyloxy)propyl]-1,2-phenylene diacetate (6) and 4-[3-(acetyloxy)propyl]- 5-nitro-1,2-phenylene diacetate (10) showed higher cytotoxicity than the parent compound 2 in tests performed on two breast cancer cell lines (MCF-7 and MDA-MB-231). The IC50 values of 40.2 ± 6.9 μM, 5.9 ± 0.8 μM and 33.8 ± 4.9 μM, respectively, were obtained without toxicity towards dermal human fibroblast (DHF cells).
- Villegas, Alejandro Madrid,Catalan, Luis Espinoza,Venegas, Ivan Montenegro,Garcia, Joan Villena,Altamirano, Hector Carrasco
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experimental part
p. 4632 - 4641
(2011/08/06)
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- Catechol diacetate derivatives for inducing the production of nerve growth factor to treat degenerative diseases in the central nervous system
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A pharmaceutical composition for the treatment of regressive disorders of the central nervous system treatable by inducing the production and secretion of nerve growth factor, containing as an active ingredient a catechol derivative of the formula STR1 where R6 is a lower alkyl group having 2 to 5 carbon atoms. The catechol derivatives provide preventative and remedial effects for regressive disorders in the central nervous system including senile dementia of the alzheimer type.
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- CONVERSION OF METHYLENEDIOXYBENZENE DERIVATIVES INTO 2-METHOXYPHENOL DERIVATIVES
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Methylenedioxybenzene derivatives are reductively cleft with diisobutylaluminum hydride to give 2-methoxyphenol derivatives.Concurrent hydroalumination occures when a substrate contains an olefinic bond in a side chain.
- Takano, Seiichi,Akiyama, Masashi,Ogasawara, Kunio
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p. 2237 - 2238
(2007/10/02)
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