- THE SYNTHESIS OF 9-OXO-9,10-DIHYDROACRIDINE-4-CARBOXYLIC ACIDS VIA THE JOURDAN-ULLMANN REACTION OF ANTHRANILIC ACIDS AND METHYL 2-IODOBENZOATES
-
Reaction between anthranilic acids and methyl 2-iodobenzoates under anhydrous Jourdan-Ullmann conditions gives good to excellent yields of 2-(2-methoxycarbonylphenyl)anthranilic acids, required precursors for the unequivocal synthesis of substituted 9-oxo
- Rewcastle, Gordon W.,Denny, William A
-
p. 309 - 318
(2007/10/02)
-
- Acridinecarboxamide compounds
-
4-Carboxamidoacridine compounds represented by the general formula (I), STR1 where R1 represents H, CH3 or NHR3, where R3 is H, COCH3, SO2 CH3, COPh, SO2 Ph or lower alkyl optionally substituted with hydroxyl and/or amino functions; R2 represents H or up to two of the groups CH3, OCH3, halogen, CF3, NO2, NH2, NHCOCH3, and NHCOOCH3 placed at positions 1-3 or 5-8; Y represents C(NH)NH2, NHC(NH)NH2, or NR4 R5, where each of R4 and R5 is H or lower alkyl optionally substituted with hydroxyl and/or amino functions; and x is from 2 to 6, and the acid addition salts thereof, possess antibacterial and antitumor properties.
- -
-
-