A compound of formula (I), or a pharmaceutically acceptable salt thereof.
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Page/Page column 57
(2020/01/24)
New pyrazole derivatives as CRAC channel modulators
The present invention relates to compounds of formula (I) which are inhibitors of CRAC channel activity. This invention also relates to pharmaceutical compositions containing them, process for their preparation and their use in therapy.
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Page/Page column 0094; 0097
(2015/03/28)
Phase transfer catalyst in grindstone synthesis of 3-oxopropanenitrile: One pot synthesis of polysubstituted amino thiophenes
The chemoselective SN2 reaction of ω-bromoacetophenone with sodium cyanide or potassium cyanide in DMF-water or in biphasic solvent toluene-water using tetrabutylammonium bromide (TBAB) as phase-transfer catalyst, performed by grinding, furnished 3-oxopropanenitriles 2 as the sole product in 70-80% yield, while in ethanolwater, mixture of compound 2 and oxirane 3 were obtained. The obtained 3-oxopropanenitriles 2 were used for one pot synthesis of 2-amino-3-carbonitrile thiophenes.
Patil, Shivaraj P.,Kanawade, Shrikant B.,Shinde, Madhukar P.,Toche, Raghunath B.
p. 33 - 36
(2013/09/24)
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