Synthesis of 5-amino-4(3H)-pyrimidinones. II. Synthesis of 5-acyl- and 5-alkylamino-3-phenyl-6-methyl-4(3H)-pyrimidinones and determination of their analgesic and antiinflammatory activities
N-Acylation and N-alkylation of 5-amino-6-methyl-3-phenyl-4(3H)-pyrimidinone (I) were carried out and the products were examined for analgesic and antiinflammatory activities. The reaction of I with α-bromopropionyl bromide or chloroacetyl chloride follow
Ueda,Sakakibara,Nakagami
p. 4263 - 4269
(2007/10/02)
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