- Production method of 2, 4, 6-tri (dimethylaminomethyl) phenol
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The invention discloses a production method of 2, 4, 6-tri (dimethylaminomethyl) phenol. The production method comprises the following steps: (1) adding formaldehyde into dimethylamine, heating to 50-60 DEG C, and reacting for 1-3 hours to obtain a solution system; (2) adding phenol into the solution system obtained in the step (1), heating to 80-90 DEG C, reacting for 1.5-4 hours, standing for layering, and carrying out oil-water separation to obtain a target product at the upper layer and a water phase at the lower layer; and (3) feeding the water phase obtained in the step (2) into double towers for rectification, extracting dimethylamine aqueous solution from the tower top of the first rectifying tower, returning to the step (1) as a raw material, feeding the aqueous solution discharged from the tower bottom of the first rectifying tower into a second rectifying tower, feeding the aqueous solution extracted from the tower top of the second rectifying tower into a biochemical device, and feeding materials discharged from the tower kettle of the second rectifying tower into the step (2) as a raw material. The production method has the advantages of high yield, few by-products andless sewage.
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Paragraph 0027-0049
(2020/05/14)
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- Triethylsiloxymethyl-N,N-dimethylamine, Et3SiOCH2NMe2: A Dimethylaminomethylation (Mannich) Reagent for O–H, S–H, P–H and Aromatic C–H Systems
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Triethylsiloxymethylamine, Et3SiOCH2NMe2, readily synthesized in high yield by the hydrosilylation reaction between Et3SiH and DMF, is an excellent (N,N-dimethylamino)methyl transfer agent to a representative range of aliphatic alcohols, thiols, and Ph2PH (E–H) materials. The reactions are almost instantaneous at room temperature in inert solvents and require no activating agents to produce E–CH2NMe2 products in high yields and illustrate the title compound as an excellent addition to the family of organic reagents. For aromatic alcohols, electrophilic substitution of the aromatic ring occurs in high yield. Crystal structures of new materials such as the cholestero–CH2NMe2 derivative, 2–4-[bis(N,N-dimethylamino)methyl]-1-naphthol, and the phosphine oxide derived from Ph2PCH2NMe2 are reported.
- Gonzalez, Paulina E.,Sharma, Hemant K.,Chakrabarty, Sanchita,Metta-Maga?a, Alejandro,Pannell, Keith H.
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p. 5610 - 5616
(2017/10/13)
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- Phenolic structure and colour in Mannich reaction products
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Mannich reactions have been carried out with a variety of model alkylphenols and dimethylamine, methylamine, and diethylenetriamine to trace the origin of persistent coloured products occurring in related reactions with pentadeca(e)nylphenol and 4-tert-alkylphenols. It was found to be attributable to the presence of resorcinolic impurities.
- Tyman, John H.P.,Patel, Mahesh
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- ENHANCEMENT OF THE RATE OF MANNICH REACTIONS IN AQUEOUS MEDIA
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The rate of Mannich reaction of phenols and of ketones with secondary amines is greatly increased in aqueous compared with alcoholic or hydrocarbon solvents.Two phase system are present and a phase transfer catalysis may be operative.With phenols and excess co-reactants the proucts are mono- or isomeric disubstituted dialkylaminomethyl derivatives dependent upon the reaction time.
- Tychopoulos, V.,Tyman, J. H. P.
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p. 1401 - 1410
(2007/10/02)
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