- Synthesis of 6H-isoindolo[2,1-a]indol-6-ones through wittig reaction and tandem reductive cyclization-lactamization
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A convenient and efficient two-step route to 6H-Isoindolo[2,1-a]indol-6- ones has been developed starting from o-nitrobenzaldehydes. The methodology involves Wittig reaction followed by tandem reductive cyclization-lactamization. A series of isoindoloindo
- Kadam, Hari K.,Tilve, Santosh G.
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p. 4280 - 4284
(2013/07/26)
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- Liver X receptor (LXR) modulators with dibenz[b,f]-[1,4]oxazepin-11-one, (Z)-dibenz[b,f]azocin-6-one, and 11,12-dihydrodibenz[b,f]azocin-6-one skeletons
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Conformationally restricted heterocyclic analogs of carba-T0901317 with dibenz[b,f][1,4]oxazepin-11-one, 11,12-dihydrodibenz[b,f)azocin-6-one, and (Z)-dibenz[b,f]-azocin-6-one skeletons were prepared as candidate for liver X receptor (LXR) agonists. In vitro transactivation assay revealed that the activity depends on the nature of the linking group.
- Aoyama, Atsushi,Aoyama, Hiroshi,Makishima, Makoto,Hashimoto, Yuichi,Miyachi, Hiroyuki
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scheme or table
p. 2209 - 2216
(2010/04/29)
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