- Synthesis of 9,9'-[1,2-Ethanediylbis(oxymethylene)]bis-2-amino- 1,9-dihydro-6H-purin-6-one, an impurity of acyclovir
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The synthesis of 9,9'-[1,2-ethanediylbis(oxymethylene)]bis-2-amino-1,9- dihydro- 6H-purin-6-one, a minor impurity of acyclovir, is described. Starting with commercial N-(9-acetyl-6-oxo-1H-purin-2-yl)acetamide, the process uses an acid catalysed phase transfer catalysis (PTC) process to produce the selective alkylation at the 9 position of the guanine ring.
- Suarez, Rosa M.,Matia, Maria Paz,Novella, Jose Luis,Molina, Andres,Cosme, Antonio,Vaquero, Juan Jose,Alvarez-Builla, Julio
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p. 8735 - 8741
(2012/11/07)
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