Highly Stereocontrolled Construction of Tricyclo1,6>dodecanes by Intramolecular Double Michael Reaction
o-Anisaldehyde has been converted, via a sigmatropic reaction and a Birch reduction, into the cyclohexenone (10) bearing an α,β-unsaturated group.Treatment of the latter with lithium hexamethyldisilazide induced an intramolecular double Michael react
STEREOCONTROLLED CONSTRUCTION OF A SPIRO FUSED BICYCLOOCTANE RING SYSTEM BY THE INTRAMOLECULAR DOUBLE MICHAEL REACTION
The lithium enolate from the cyclohexenone (8) possessing the α,β-unsaturated ester moiety caused an intramolecular double Michael reaction to produce stereoselectively the spiro fused bicyclo-octane (10).