- Acylhydrazone Subunits as a Proton Cargo Delivery System in 7-Hydroxyquinoline
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The reimagined concept of long-range tautomeric proton transfer using crane subunits is shown by designing and synthesising two new acylhydrazones containing a 7-hydroxyquinoline (7-OHQ) platform. The acylhydrazone subunits attached to the 7-OHQ at the 8t
- Antonov, Liudmil,Georgiev, Anton,Hirashima, Shin-ichi,Hori, Yutaro,Matsushima, Yasuyuki,Miura, Tsuyoshi,Nakashima, Kosuke,Petek, Anton,Yordanov, Dancho
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supporting information
p. 11559 - 11566
(2021/07/16)
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- A Dearomatization/Debromination Strategy for the [4+1] Spiroannulation of Bromophenols with α,β-Unsaturated Imines
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A novel [4+1] spiroannulation of o- & p-bromophenols with α,β-unsaturated imines has been developed for the direct synthesis of a new family of azaspirocyclic molecules. Notably, several other halophenols (X=Cl, I) were also applicable for this transformation. Moreover, a catalytic asymmetric version of the reaction was realized with 1-bromo-2-naphthols by using a chiral ScIII/Py-Box catalyst. Mechanistic studies revealed that this domino reaction proceeded through electrophile-triggered dearomatization of phenol derivatives at their halogenated positions and followed by halogen-displacement with N-nucleophiles via a radical-based SRN1 mechanism.
- Bai, Lu,Ge, Yicong,Hao, Jiamao,Liu, Jingjing,Luan, Xinjun,Qin, Cheng
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supporting information
p. 18985 - 18989
(2020/08/26)
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- MODULATORS OF CXCR7
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Compounds having formula (I) or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present inven
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Page/Page column 52-53
(2010/06/11)
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