- Using Molecular Architecture to Control the Reactivity of a Triplet Vinylnitrene
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Photolysis of 3-azido-1-indenone (1) with a light-emitting diode (LED, λ = 405 nm) or mercury arc lamp (Pyrex) resulted in the formation of heterodimer 3 in excellent yield, through dimerization of triplet vinylnitrene 32. At ambient temperatur
- Sarkar, Sujan K.,Osisioma, Onyinye,Karney, William L.,Abe, Manabu,Gudmundsdottir, Anna D.
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- Ir-catalyzed asymmetric hydrogenation of 3-arylindenones for the synthesis of chiral 3-arylindanones
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An efficient synthesis of chiral 3-arylindanones via iridium-catalyzed asymmetric hydrogenation of 3-arylindenones has been developed. The reaction showed good compatibility with various functional groups, delivering a variety of 3-arylindanones in excellent yields and with good enantioselectivities. The reaction was also carried out on a gram-scale, delivering the product in quantitative yield. In addition, the products can be easily derivatized and transformed into natural products and pharmaceutical agents.
- Yan, Jun,Nie, Yu,Gao, Feng,Yuan, Qianjia,Xie, Fang,Zhang, Wanbin
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supporting information
(2021/02/27)
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- Stereoselective Photodimerization of 3-Arylindenones in Solution and in the Solid State
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Photodimerization of 3-arylindenones in solution and in the solid state was examined. Irradiation of 3-arylindenones in benzene exclusively gave C2-symmetric anti-HH cyclobutane dimers in good yields. In contrast, photolysis in the solid state
- Uemura, Naohiro,Ishikawa, Hiroki,Tamura, Naoki,Yoshida, Yasushi,Mino, Takashi,Kasashima, Yoshio,Sakamoto, Masami
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p. 2256 - 2262
(2018/02/23)
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- Synthesis of benzo[c]fluorenone through a one-pot cascade reaction using inden-1-one derivatives
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A novel one-pot thermal cycloaddition of two indenones followed by a decarbonylation and dehydrogenation cascade afforded benzo[c]fluorenones regioselectively. Various substituted indenone derivatives were converted into their corresponding benzo[c]fluorenones in good to excellent yields.
- Zheng, Shuyan,Tan, Hongsheng,Zhang, Xiaoguang,Yu, Chunhui,Shen, Zhengwu
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supporting information
p. 975 - 978
(2015/02/02)
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- Synthesis of benzo[c]fluorenone through a one-pot cascade reaction using inden-1-one derivatives
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A novel one-pot thermal cycloaddition of two indenones followed by a decarbonylation and dehydrogenation cascade afforded benzo[c]fluorenones regioselectively. Various substituted indenone derivatives were converted into their corresponding benzo[c]fluorenones in good to excellent yields.
- Zheng, Shuyan,Tan, Hongsheng,Zhang, Xiaoguang,Yu, Chunhui,Shen, Zhengwu
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supporting information
p. 975 - 978
(2014/02/14)
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- TREATMENT OF NEURODEGENERATIVE DISEASES USING INDATRALINE ANALOGS
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Methods and compositions useful in the treatment or prevention of synucleinopathies, such as Parkinson''s disease, diffuse Lewy body disease, and multiple system atrophy, or other neurodegenerative diseases (e.g., amyotrophic lateral sclerosis, Huntington''s disease, and Alzheimer''s disease) are provided. The treatment including administering to a subject an indatraline derivative that inhibits the aggregation of a-synuclein.
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Page/Page column 101
(2009/04/25)
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- Synthesis and pharmacological activity of aminoindanone dimers and related compounds
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A series of N-substituted 3-aminoindanones were synthesised and evaluated for smooth muscle relaxant activity and mediator release inhibition effects. A low level of smooth muscle relaxant activity has been identified in all derivatives. Data have revealed that the significant mediator release inhibition effects observed are related to the nature of the amine substituents. A structure activity relationship is proposed.
- Sheridan,Butterly,Walsh,Cogan,Jordan,Nolan,Frankish
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p. 248 - 254
(2008/09/16)
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- Indene and pseudoazulene discotic liquid crystals: A synthetic and structural study
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Several new liquid-crystalline indene and pseudoazulene systems are reported. These molecules give rise to either columnar hexagonal mesophases and/or columnar plastic phases. The unique nature of these compounds stems from their non-classical discotic st
- Basurto, Sara,Garcia, Susana,Neo, Ana G.,Torroba, Tomas,Marcos, Carlos F.,Miguel, Daniel,Barbera, Joaquin,Blanca Ros,Rosario De La Fuente
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p. 5362 - 5376
(2007/10/03)
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- Synthesis of indatraline using a Suzuki cross-coupling reaction and a chemoselective hydrogenation: A versatile approach
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Indatraline and its derivatives can be obtained in five steps from indanone by using a Suzuki cross-coupling reaction and a chemoselective hydrogenation catalyzed by Wilkinson's catalyst.
- Cossy, Janine,Belotti, Damien,Maguer, Aude
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p. 1515 - 1517
(2007/10/03)
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- Photobromination of indane: Preparation of bromoindenones and ready access to benzo[c]fluorenone skeleton
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1,1,3,3-Tetrabromoindane and 1,1,2,3,3-pentabromoindane were efficiently synthesized by photolytic bromination of indane. Subsequent dehydrobromination of them gave the corresponding tribromo- and tetrabromoindenes, which were easily converted to the corresponding bromoindenones by silver-supported hydrolysis. Thermolysis of 3-bromoindenone gave the benzo[c]fluorenone derivative.
- Tutar, Ahmet,Cakmak, Osman,Balci, Metin
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p. 9759 - 9763
(2007/10/03)
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- Synthetic routes to ninhydrins. Preparation of ninhydrin, 5-methoxyninhydrin, and 5-(methylthio)ninhydrin
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Two syntheses of 5-methoxyninhydrin (2,2-dihydroxy-5-methoxy-1,3-indanedione) are described. One method employs a novel and efficient two step route, which begins with commercially available 6-methoxy-1-indanone. The application of this strategy for the preparation of a new ninhydrin derivative, 5-(methylthio)ninhydrin, and ninhydrin is also presented.
- Heffner,Joullie
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p. 2231 - 2256
(2007/10/02)
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