- BETA-LACTAMASE INHIBITOR
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A beta-lactamase inhibitor having a formula (I). Also provided is a method of using the beta-lactamase inhibitor for prevention or treatment of diseases.
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Paragraph 0041; 0042
(2019/02/24)
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- PREPARATION OF PYRIDINE DERIVATIVES USING PYRIMIDINIUM DERIVATIVES AS INTERMEDIATES
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A method in which a pyridinium derivative of formula (I) such as 1,3-dimethyl-2,3-dihydro-2-oxopyrimidinium chloride is reacted with an acetyl compound of formula (II) such as 4-acetylpyridine, and then the reaction product is reacted with ammonia or an ammonium salt to form a pyridine derivative of formula (III):Also disclosed is a method for the preparation of the compound of formula (I) from reacting a compound of formula (IV) or (V) with a compound of formula (VI):Also disclosed are two additional alternative methods for the preparation of compounds of formula (I) and related compounds. The substituents are defined in the claims.
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Page/Page column 25
(2008/06/13)
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- PALLADIUM CATALYSED SYNTHESIS OF N AND S HETEROCYCLIC ESTERS
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Palladium catalysed alkoxycarbonylation of heterocyclic halides affords a simple and versatile synthesis of both N and S heterocyclic esters where a range of catalysts have been studied and a method to employ inexpensive inorganic bases has been found.
- Head, Robert A.,Ibbotson, Arthur
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p. 5939 - 5942
(2007/10/02)
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A number of new 3,5-disubstituted-N-methyl-pyridium salts were synthesized. By Na2S2O4 and NaBH4 reduction, the corresponding dihydropyridines were obtained. The structures (ratio of isomers) of the reduction products were determined by UV, IR and NMR spectroscopy. The relationship between the Z-values of several solvents of varying polarity, and the electronspectra of the dihydropyridines was established. This allowed an estimation, to what extent dipolar structures participate in the ground- and excited state of the dihydropyridine molecules. So one observes that the groundstate already exhibits to a large extent dipolar character. On the basis of the electrongas model, Stoerpotentiale were calculated from the absorption-spectra of dihydropyridines and therefrom the double bond character in the chromophore was estimated. Such values could also be calculated from bond lengths for one of the compounds whered X-ray analysis already exists. The results of the different methods used, agree with each other. The double-band UV spectrum in different disubstituted 1,6-dihydropyridines is discussed on the grounds of the existing data for the position and intensity of both maxima. The proposition is made that the absorption at longer wavelength is due to the amino-diene, 1-amino-4-cyano-chromophore resp., the one at shorter wavelength due to a β-aminoacrylic acid-like system.
- Hanstein, W,Wallenfels, K
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p. 585 - 601
(2007/10/08)
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