Cytotoxic dimers comprising CBI-based and/or CPI-based sub-units, antibody drug conjugates comprising such dimers, and to methods for using the same to treat cancer and other conditions.
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Page/Page column 94-95
(2018/11/02)
Synthesis, cytostatic and trichomonacide activities of 3,5-bis-(halomethyl)pyrazoles
SYNTHESIS OF NEW MACROCYCLIC POLYETHER DI- OR TETRAESTER LIGANDS CONTAINING PYRAZOLE UNITS
A new series of macrocyclic polyether - diester compounds containing one or two pyrazole rings (NH or N-methyl substituted) have been prepared by treating 3,5-pyrazolyldicarbonyl chlorides with tetraethylene glycol in the presence of triethylamine.Their complexation abilities towards the shift reagent Eu(Fod)3 have been studied by 1H NMR in CDCl3 solution.
Elguero, J.,Navarro, P.,Franco, M. I. Rodriguez
p. 425 - 428
(2007/10/02)
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